Anterior medial temporal lobe activation during encoding of words: FMRI methods to optimize sensitivity

Michael W. Parsons, Marc W. Haut, Susan K. Lemieux, Maria Moran, Sharon G. Leach

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The existence of a rostrocaudal gradient of medial temporal lobe (MTL) activation during memory encoding has historically received support from positron emission tomography studies, but less so from functional MRI (FMRI) studies. More recently, FMRI studies have demonstrated that characteristics of the stimuli can affect the location of activation seen in the MTL when those stimuli are encoded. The current study tested the hypothesis that MTL activation during memory encoding is related to the modality of stimulus presentation. Subjects encoded auditorily or visually presented words in an FMRI novelty paradigm. Imaging and analysis parameters were optimized to minimize susceptibility artifact in the anterior MTL. Greater activation was observed in the anterior than posterior MTL for both modalities of stimulus presentation. The results indicate that anterior MTL activation occurred during encoding, independent of stimulus modality and provide support for the hypothesis that verbal-semantic memory processing occurs in anterior MTL. The authors suggest that technical factors are critical for observing the rostrocaudal gradient in MTL memory activation.

Original languageEnglish (US)
Pages (from-to)253-261
Number of pages9
JournalBrain and cognition
Volume60
Issue number3
DOIs
StatePublished - Apr 1 2006

Fingerprint

Temporal Lobe
Magnetic Resonance Imaging
Medial Temporal Lobe
Encoding
Activation
Functional MRI
Semantics
Positron-Emission Tomography
Artifacts
Stimulus
Modality

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology

Cite this

Parsons, Michael W. ; Haut, Marc W. ; Lemieux, Susan K. ; Moran, Maria ; Leach, Sharon G. / Anterior medial temporal lobe activation during encoding of words : FMRI methods to optimize sensitivity. In: Brain and cognition. 2006 ; Vol. 60, No. 3. pp. 253-261.
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Anterior medial temporal lobe activation during encoding of words : FMRI methods to optimize sensitivity. / Parsons, Michael W.; Haut, Marc W.; Lemieux, Susan K.; Moran, Maria; Leach, Sharon G.

In: Brain and cognition, Vol. 60, No. 3, 01.04.2006, p. 253-261.

Research output: Contribution to journalArticle

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