TY - CHAP
T1 - Anthocyanins as apoptotic regulators
AU - Vanamala, Jairam
AU - Radhakrishnan, Sridhar
AU - Reddivari, Lavanya
AU - Massey, Aaron
N1 - Publisher Copyright:
© 2012 Springer Science+Business Media Dordrecht. All rights are reserved.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Bioactive compounds have been used traditionally in different cultures to promote human health. Anthocyanins (ACNs) are one of the most abundant dietary bioactive compounds and are responsible for the bright red, blue and purple colors of fruits and vegetables. There are over 600 different types of ACNs in nature, featuring six common aglycone structures, with different side chains attached. Although ACN bioavailability is low, ACNs and their gut metabolites possess biological activities that positively impact a variety of chronic diseases including cancer. This book chapter provides a brief summary of the synthesis and the bioavailability of ACNs and discusses the molecular mechanisms involved in ACN-induced apoptosis in cell culture, animal models and human clinical studies. Furthermore, ACN metabolism in vivo is also discussed, as the evidence indicates that the ACN meta-bolites are important pro-apoptotic agents. We hope that the presented evidence will help influence future research in the direction of furthering the scientific understanding of ACN pro-apoptotic properties in cancer.
AB - Bioactive compounds have been used traditionally in different cultures to promote human health. Anthocyanins (ACNs) are one of the most abundant dietary bioactive compounds and are responsible for the bright red, blue and purple colors of fruits and vegetables. There are over 600 different types of ACNs in nature, featuring six common aglycone structures, with different side chains attached. Although ACN bioavailability is low, ACNs and their gut metabolites possess biological activities that positively impact a variety of chronic diseases including cancer. This book chapter provides a brief summary of the synthesis and the bioavailability of ACNs and discusses the molecular mechanisms involved in ACN-induced apoptosis in cell culture, animal models and human clinical studies. Furthermore, ACN metabolism in vivo is also discussed, as the evidence indicates that the ACN meta-bolites are important pro-apoptotic agents. We hope that the presented evidence will help influence future research in the direction of furthering the scientific understanding of ACN pro-apoptotic properties in cancer.
UR - http://www.scopus.com/inward/record.url?scp=84932184088&partnerID=8YFLogxK
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U2 - 10.1007/978-94-007-4917-7_4
DO - 10.1007/978-94-007-4917-7_4
M3 - Chapter
AN - SCOPUS:84932184088
SN - 9400749163
SN - 9789400749160
VL - 9789400749177
SP - 93
EP - 122
BT - Novel Apoptotic Regulators in Carcinogenesis
PB - Springer Netherlands
ER -