Abstract
Antibodies against nuclear protein kinase NII were detected by radioimmunoassay in the sera of patients with systemic lupus erythematosus and mixed connective tissue disease but not in sera from normal individuals or from patients with rheumatoid arthritis. Immunoglobulins derived from sera containing the antikinase antibodies inhibited the activity of protein kinase NII in vitro but had no effect on the activity of cytoplasmic cyclic AMP-dependent protein kinase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2077-2079 |
| Number of pages | 3 |
| Journal | Journal of Biological Chemistry |
| Volume | 259 |
| Issue number | 4 |
| State | Published - Apr 5 1984 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology
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Anti-protein kinase NII antibodies in rheumatic autoimmune diseases. / Stetler, D. A.; Rose, K. M.; Wenger, M. E.; Berlin, Cheston; Jacob, S. T.
In: Journal of Biological Chemistry, Vol. 259, No. 4, 05.04.1984, p. 2077-2079.Research output: Contribution to journal › Article
TY - JOUR
T1 - Anti-protein kinase NII antibodies in rheumatic autoimmune diseases
AU - Stetler, D. A.
AU - Rose, K. M.
AU - Wenger, M. E.
AU - Berlin, Cheston
AU - Jacob, S. T.
PY - 1984/4/5
Y1 - 1984/4/5
N2 - Antibodies against nuclear protein kinase NII were detected by radioimmunoassay in the sera of patients with systemic lupus erythematosus and mixed connective tissue disease but not in sera from normal individuals or from patients with rheumatoid arthritis. Immunoglobulins derived from sera containing the antikinase antibodies inhibited the activity of protein kinase NII in vitro but had no effect on the activity of cytoplasmic cyclic AMP-dependent protein kinase.
AB - Antibodies against nuclear protein kinase NII were detected by radioimmunoassay in the sera of patients with systemic lupus erythematosus and mixed connective tissue disease but not in sera from normal individuals or from patients with rheumatoid arthritis. Immunoglobulins derived from sera containing the antikinase antibodies inhibited the activity of protein kinase NII in vitro but had no effect on the activity of cytoplasmic cyclic AMP-dependent protein kinase.
UR - http://www.scopus.com/inward/record.url?scp=0021358914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021358914&partnerID=8YFLogxK
M3 - Article
VL - 259
SP - 2077
EP - 2079
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 4
ER -