Antibacterial activities of iron chelators against common nosocomial pathogens

Mitchell G. Thompson, Brendan W. Corey, Yuanzheng Si, David W. Craft, Daniel V. Zurawski

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.

Original languageEnglish (US)
Pages (from-to)5419-5421
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume56
Issue number10
DOIs
StatePublished - Oct 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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