Antibacterial and hemolytic activities of pyridinium polymers as a function of the spatial relationship between the positive charge and the pendant alkyl tail

Varun Sambhy, Blake R. Peterson, Ayusman Sen

Research output: Contribution to journalArticlepeer-review

193 Scopus citations

Abstract

(Figure Presented) The benefits of separation: For homologous polymers having similar backbone composition and charge/tail ratios, placing the charge and alkyl tail on spatially separated centers results in a higher membrane-disrupting ability, as evident from the increased antibacterial and hemolyticac tivities. The spatial separation particularly amplifies mammalian cell toxicity (see picture).

Original languageEnglish (US)
Pages (from-to)1250-1254
Number of pages5
JournalAngewandte Chemie - International Edition
Volume47
Issue number7
DOIs
StatePublished - Feb 1 2008

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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