Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701

KH Ahammad Uz Zaman, Xiaohua Wu, Zhenquan Hu, Wesley Yoshida, Shaobin Hou, Jennifer Saito, Kristiana Alexes Avad, Kirk E. Hevener, John N. Alumasa, Shugeng Cao

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Alarming rate of resistance to the existing antibiotics exhibits the importance of developing new antibiotic molecules from relatively under explored sources as well as implementing alternative approaches like antibiotic adjuvants. Six previously undescribed fungal polyketides, kaneoheoic acids A-F (1–6) were isolated from a fungal strain Fusarium sp. FM701 which was collected from a muddy sample of Hawaiian beach. The structures of these six compounds were elucidated by spectroscopic interpretation, including HRESIMS and NMR, and electronic circular dichroism (ECD) analysis. All six compounds that were inactive when tested alone showed significant antibacterial activity against Staphylococcus aureus and Bacillus subtilis, in the range of 10–80 μg/mL when assayed in combination with either chloramphenicol (half of the MIC, 1 μg/mL), an FDA approved antibiotic or disulfiram (6 μg/mL), an established antibiotic adjuvant that augmented the activity of antibiotics.

Original languageEnglish (US)
Article number112545
JournalPhytochemistry
Volume181
DOIs
StatePublished - Jan 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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