@article{f9b120c73b6a40eb8ddead73e97be5ff,
title = "Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701",
abstract = "Alarming rate of resistance to the existing antibiotics exhibits the importance of developing new antibiotic molecules from relatively under explored sources as well as implementing alternative approaches like antibiotic adjuvants. Six previously undescribed fungal polyketides, kaneoheoic acids A-F (1–6) were isolated from a fungal strain Fusarium sp. FM701 which was collected from a muddy sample of Hawaiian beach. The structures of these six compounds were elucidated by spectroscopic interpretation, including HRESIMS and NMR, and electronic circular dichroism (ECD) analysis. All six compounds that were inactive when tested alone showed significant antibacterial activity against Staphylococcus aureus and Bacillus subtilis, in the range of 10–80 μg/mL when assayed in combination with either chloramphenicol (half of the MIC, 1 μg/mL), an FDA approved antibiotic or disulfiram (6 μg/mL), an established antibiotic adjuvant that augmented the activity of antibiotics.",
author = "{Uz Zaman}, {KH Ahammad} and Xiaohua Wu and Zhenquan Hu and Wesley Yoshida and Shaobin Hou and Jennifer Saito and Avad, {Kristiana Alexes} and Hevener, {Kirk E.} and Alumasa, {John N.} and Shugeng Cao",
note = "Funding Information: This work was financially supported by start-up funding from Daniel K. Inouye College of Pharmacy (DKICP), Seed Grants from University of Hawaii at Hilo (UHH), and the Victoria S. and Bradley L. Geist Foundation (15ADVC-74420, 17CON-86295, and 20CON-102163) (to SC). Funding for this work was also supported by Hawaii IDeA Network for Biomedical Research Excellence III and IV (INBRE-III and INBRE-IV) project: NIGMS Grant 5P20GM103466. We would also like to express our gratitude to Mr. Justin Reinicke for his help with NMR and for his kind assistance with optical rotation and ECD data collection. Funding Information: This work was financially supported by start-up funding from Daniel K. Inouye College of Pharmacy (DKICP), Seed Grants from University of Hawaii at Hilo (UHH), and the Victoria S. and Bradley L. Geist Foundation ( 15ADVC-74420 , 17CON-86295 , and 20CON-102163 ) (to SC). Funding for this work was also supported by Hawaii IDeA Network for Biomedical Research Excellence III and IV (INBRE- III and INBRE- IV ) project: NIGMS Grant 5P20GM103466 . We would also like to express our gratitude to Mr. Justin Reinicke for his help with NMR and for his kind assistance with optical rotation and ECD data collection. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2021",
month = jan,
doi = "10.1016/j.phytochem.2020.112545",
language = "English (US)",
volume = "181",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Elsevier Limited",
}