Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures

Susan F. Gonsalves, Bonnie Twitchell, Robert Harbaugh, Povl Krogsgaard-Larsen, Arne Schousboe

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Abstract

The antiseizure activity of the glia-selective GABA uptake inhibitor, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO), was evaluated in rats in models of acute chemoconvulsion. In these experiments, intracerebroventricular administration of the drug 30 min prior to testing in doses between 100-750 μg provided protection against maximal pentylenetetrazol seizures and increased the latency to isonicotinic acid hydrazide seizures. Pentylenetetrazol seizure thresholds, in contrast, were not significantly elevated. The ability of THAO to suppress tonic but not generalized minor seizures suggests that it may block seizure spread.

Original languageEnglish (US)
Pages (from-to)265-268
Number of pages4
JournalEuropean Journal of Pharmacology
Volume168
Issue number2
DOIs
Publication statusPublished - Sep 13 1989

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All Science Journal Classification (ASJC) codes

  • Pharmacology

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