Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures

Susan F. Gonsalves, Bonnie Twitchell, Robert Harbaugh, Povl Krogsgaard-Larsen, Arne Schousboe

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The antiseizure activity of the glia-selective GABA uptake inhibitor, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO), was evaluated in rats in models of acute chemoconvulsion. In these experiments, intracerebroventricular administration of the drug 30 min prior to testing in doses between 100-750 μg provided protection against maximal pentylenetetrazol seizures and increased the latency to isonicotinic acid hydrazide seizures. Pentylenetetrazol seizure thresholds, in contrast, were not significantly elevated. The ability of THAO to suppress tonic but not generalized minor seizures suggests that it may block seizure spread.

Original languageEnglish (US)
Pages (from-to)265-268
Number of pages4
JournalEuropean Journal of Pharmacology
Volume168
Issue number2
DOIs
StatePublished - Sep 13 1989

Fingerprint

GABA Uptake Inhibitors
Neuroglia
Anticonvulsants
Seizures
Pentylenetetrazole
Isoniazid
5,6,7,8-tetrahydro-4H-isoxazolo(4,5-c)azepin-3-ol
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Gonsalves, Susan F. ; Twitchell, Bonnie ; Harbaugh, Robert ; Krogsgaard-Larsen, Povl ; Schousboe, Arne. / Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures. In: European Journal of Pharmacology. 1989 ; Vol. 168, No. 2. pp. 265-268.
@article{9f3e2ff32b194c36b516a56b77e6b0b4,
title = "Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures",
abstract = "The antiseizure activity of the glia-selective GABA uptake inhibitor, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO), was evaluated in rats in models of acute chemoconvulsion. In these experiments, intracerebroventricular administration of the drug 30 min prior to testing in doses between 100-750 μg provided protection against maximal pentylenetetrazol seizures and increased the latency to isonicotinic acid hydrazide seizures. Pentylenetetrazol seizure thresholds, in contrast, were not significantly elevated. The ability of THAO to suppress tonic but not generalized minor seizures suggests that it may block seizure spread.",
author = "Gonsalves, {Susan F.} and Bonnie Twitchell and Robert Harbaugh and Povl Krogsgaard-Larsen and Arne Schousboe",
year = "1989",
month = "9",
day = "13",
doi = "10.1016/0014-2999(89)90576-1",
language = "English (US)",
volume = "168",
pages = "265--268",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2",

}

Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures. / Gonsalves, Susan F.; Twitchell, Bonnie; Harbaugh, Robert; Krogsgaard-Larsen, Povl; Schousboe, Arne.

In: European Journal of Pharmacology, Vol. 168, No. 2, 13.09.1989, p. 265-268.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures

AU - Gonsalves, Susan F.

AU - Twitchell, Bonnie

AU - Harbaugh, Robert

AU - Krogsgaard-Larsen, Povl

AU - Schousboe, Arne

PY - 1989/9/13

Y1 - 1989/9/13

N2 - The antiseizure activity of the glia-selective GABA uptake inhibitor, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO), was evaluated in rats in models of acute chemoconvulsion. In these experiments, intracerebroventricular administration of the drug 30 min prior to testing in doses between 100-750 μg provided protection against maximal pentylenetetrazol seizures and increased the latency to isonicotinic acid hydrazide seizures. Pentylenetetrazol seizure thresholds, in contrast, were not significantly elevated. The ability of THAO to suppress tonic but not generalized minor seizures suggests that it may block seizure spread.

AB - The antiseizure activity of the glia-selective GABA uptake inhibitor, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO), was evaluated in rats in models of acute chemoconvulsion. In these experiments, intracerebroventricular administration of the drug 30 min prior to testing in doses between 100-750 μg provided protection against maximal pentylenetetrazol seizures and increased the latency to isonicotinic acid hydrazide seizures. Pentylenetetrazol seizure thresholds, in contrast, were not significantly elevated. The ability of THAO to suppress tonic but not generalized minor seizures suggests that it may block seizure spread.

UR - http://www.scopus.com/inward/record.url?scp=0024470501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024470501&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(89)90576-1

DO - 10.1016/0014-2999(89)90576-1

M3 - Article

C2 - 2532604

AN - SCOPUS:0024470501

VL - 168

SP - 265

EP - 268

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -