Antigen presentation by liposomes: Inhibition with antibodies

Peter Walden, Zoltan A. Nagy, Jan Klein

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The involvement of both antigen and class II major histocompatibility complex (MHC) molecules in T cell activation by liposome‐bound antigens was investigated. We used a pigeon cytochrome c (PCC)‐specific Ek‐restricted T cell hybridoma that can be activated to produce interleukin 2 by liposomes carrying either PCC and Ek molecules, or a high concentration of PCC alone. We demonstrated that the MHC‐restricted response of this hybridoma to liposomes is specifically blocked by both anti‐MHC and anti‐PCC monoclonal antibodies, whereas unrestricted activation is only inhibited by PCC‐specific antibody.

Original languageEnglish (US)
Pages (from-to)717-720
Number of pages4
JournalEuropean Journal of Immunology
Volume16
Issue number6
DOIs
StatePublished - 1986

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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