Antimalarial drugs and heme in detergent micelles: An NMR study

Leah B. Casabianca, Joye B. Kallgren, Jayakumar K. Natarajan, John N. Alumasa, Paul D. Roepe, Christian Wolf, Angel C. de Dios

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Proton nuclear magnetic resonance relaxation times were measured for the protons of micelles formed by the detergents sodium dodecyl sulfate, dodecyltrimethyl ammonium bromide, and polyethylene glycol sorbitan monolaureate in the presence of ferriprotoporphyrin IX and the antimalarial drugs chloroquine, 7-chloro-4-quinolyl 4-N,N-diethylaminobutyl sulfide, and primaquine. Diffusion coefficients were extracted from pulsed gradient NMR experiments to evaluate the degree of association of these drugs with the detergent micelles. Results indicate that at low or neutral pH when the quinolyl N is protonated, chloroquine does not associate with neutral or cationic detergent micelles. For this reason, chloroquine's interaction with heme perturbs the partitioning of heme between the aqueous medium and detergent micelles.

Original languageEnglish (US)
Pages (from-to)745-748
Number of pages4
JournalJournal of Inorganic Biochemistry
Volume103
Issue number5
DOIs
StatePublished - May 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Inorganic Chemistry

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    Casabianca, L. B., Kallgren, J. B., Natarajan, J. K., Alumasa, J. N., Roepe, P. D., Wolf, C., & de Dios, A. C. (2009). Antimalarial drugs and heme in detergent micelles: An NMR study. Journal of Inorganic Biochemistry, 103(5), 745-748. https://doi.org/10.1016/j.jinorgbio.2009.01.013