Antimicrobial activity of Solanum aculeastrum

Srinivas Koduru, D. S. Grierson, A. J. Afolayan

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Solanum aculeastrum Dunal (Solanaceae) is used in traditional medicine to treat various human and animal diseases, specifically stomach disorders and various cancers, in the Eastern Cape, South Africa. The fruit and leaf extracts of this plant were investigated for in vitro antimicrobial activity against 10 selected bacterial and 5 fungal strains. The methanolic extracts of both the fruits and the leaves showed appreciable activity against Gram-positive and Gram-negative bacteria ranging from 4.0 to 10.0 mg/ml. Whereas the methanol extracts were the most active material, the water extracts showed the least activity against the bacteria. The methanol extracts were particularly inhibitory to the growth of the fungi with percentage inhibition ranging from 60.26% to 100% and 56.0% to 100% on Aspergillus flavus and Pencillium notatum, respectively. The acetone extracts were active against Aspergillus flavus (100%) and Pencillium notatum (64.81%), and the water extract of the fruit significantly inhibited the growth of P. notatum (69.89%). The most resistant organisms were Aspergillus niger, Candida albicans, and Fusarium oxysporum.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalPharmaceutical Biology
Volume44
Issue number4
DOIs
StatePublished - Jun 1 2006

Fingerprint

Solanum
Aspergillus flavus
Fruit
Methanol
Solanaceae
Animal Diseases
Plant Leaves
Aspergillus niger
Water
Plant Extracts
Fusarium
Traditional Medicine
Growth
Acetone
South Africa
Gram-Negative Bacteria
Candida albicans
Stomach
Fungi
Bacteria

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Koduru, Srinivas ; Grierson, D. S. ; Afolayan, A. J. / Antimicrobial activity of Solanum aculeastrum. In: Pharmaceutical Biology. 2006 ; Vol. 44, No. 4. pp. 283-286.
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Antimicrobial activity of Solanum aculeastrum. / Koduru, Srinivas; Grierson, D. S.; Afolayan, A. J.

In: Pharmaceutical Biology, Vol. 44, No. 4, 01.06.2006, p. 283-286.

Research output: Contribution to journalArticle

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