Antimicrobial nanotechnology: Its potential for the effective management of microbial drug resistance and implications for research needs in microbial nanotoxicology

Deborah Michiko Aruguete, Bojeong Kim, Michael F. Hochella, Yanjun Ma, Yingwen Cheng, Andy Hoegh, Jie Liu, Amy Pruden

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

The development of antibiotics revolutionized human health, providing a simple cure for once dreaded diseases such as tuberculosis. However, widespread production, use, and mis-use of antibiotics have contributed to the next-generation concern for global public health: the emergence of multiple drug-resistant (MDR) infectious organisms (a.k.a. "superbugs"). Recently, nanotechnology, specifically the use of nanomaterials (NMs) with antimicrobial activity, has been presented as a new defense against MDR infectious organisms. We discuss the potential for NMs to either circumvent microbial resistance or induce its development in light of our current state of knowledge, finding that this question points to a need for fundamental research targeting the molecular mechanisms causing antimicrobial activity in NMs. In the context of current microbial nanotoxicology studies, particularly reductionist laboratory studies, we offer suggestions and considerations for future research, using an illustrative example from our work with silver nanoparticles.

Original languageEnglish (US)
Pages (from-to)93-102
Number of pages10
JournalEnvironmental Sciences: Processes and Impacts
Volume15
Issue number1
DOIs
StatePublished - Mar 6 2013

Fingerprint

drug resistance
Nanotechnology
nanotechnology
antimicrobial activity
Nanostructures
Microbial Drug Resistance
Nanostructured materials
antibiotics
drug
tuberculosis
Research
Pharmaceutical Preparations
Anti-Bacterial Agents
targeting
public health
silver
Public health
Silver
Nanoparticles
Tuberculosis

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Management, Monitoring, Policy and Law

Cite this

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Antimicrobial nanotechnology : Its potential for the effective management of microbial drug resistance and implications for research needs in microbial nanotoxicology. / Aruguete, Deborah Michiko; Kim, Bojeong; Hochella, Michael F.; Ma, Yanjun; Cheng, Yingwen; Hoegh, Andy; Liu, Jie; Pruden, Amy.

In: Environmental Sciences: Processes and Impacts, Vol. 15, No. 1, 06.03.2013, p. 93-102.

Research output: Contribution to journalReview article

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T2 - Its potential for the effective management of microbial drug resistance and implications for research needs in microbial nanotoxicology

AU - Aruguete, Deborah Michiko

AU - Kim, Bojeong

AU - Hochella, Michael F.

AU - Ma, Yanjun

AU - Cheng, Yingwen

AU - Hoegh, Andy

AU - Liu, Jie

AU - Pruden, Amy

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