Antimicrobial resistance determinant microarray for analysis of multi-drug resistant isolates

Chris Rowe Taitt, Tomasz Leski, David Stenger, Gary J. Vora, Brent House, Matilda Nicklasson, Guillermo Pimentel, Daniel V. Zurawski, Benjamin C. Kirkup, David Craft, Paige E. Waterman, Emil P. Lesho, Umaru Bangura, Rashid Ansumana

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The prevalence of multidrug-resistant infections in personnel wounded in Iraq and Afghanistan has made it challenging for physicians to choose effective therapeutics in a timely fashion. To address the challenge of identifying the potential for drug resistance, we have developed the Antimicrobial Resistance Determinant Microarray (ARDM) to provide DNAbased analysis for over 250 resistance genes covering 12 classes of antibiotics. Over 70 drug-resistant bacteria from different geographic regions have been analyzed on ARDM, with significant differences in patterns of resistance identified: genes for resistance to sulfonamides, trimethoprim, chloramphenicol, rifampin, and macrolide-lincosamidesulfonamide drugs were more frequently identified in isolates from sources in Iraq/Afghanistan. Of particular concern was the presence of genes responsible for resistance to many of the last-resort antibiotics used to treat war traumaassociated infections.

Original languageEnglish (US)
Title of host publicationSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX
Volume8371
DOIs
StatePublished - Jul 23 2012
EventSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX - Baltimore, MD, United States
Duration: Apr 23 2012Apr 25 2012

Other

OtherSensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX
CountryUnited States
CityBaltimore, MD
Period4/23/124/25/12

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Taitt, C. R., Leski, T., Stenger, D., Vora, G. J., House, B., Nicklasson, M., Pimentel, G., Zurawski, D. V., Kirkup, B. C., Craft, D., Waterman, P. E., Lesho, E. P., Bangura, U., & Ansumana, R. (2012). Antimicrobial resistance determinant microarray for analysis of multi-drug resistant isolates. In Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX (Vol. 8371). [83710X] https://doi.org/10.1117/12.924569