Antimicrobial Scaffolds

Andrew W. Simonson, Matthew R. Aronson, Scott H. Medina, Scott H. Medina

Research output: Contribution to journalReview article

Abstract

Antimicrobial discovery in the age of antibiotic resistance has demanded the prioritization of non-conventional therapies that act on new targets or employ novel mechanisms. Among these, supramolecular antimicrobial peptide assemblies have emerged as attractive therapeutic platforms, operating as both the bactericidal agent and delivery vector for combinatorial antibiotics. Leveraging their programmable inter- A nd intra-molecular interactions, peptides can be engineered to form higher ordered monolithic or co-assembled structures, including nano-fibers,-nets, and-tubes, where their unique bifunctionalities often emerge from the supramolecular state. Further advancements have included the formation of macroscopic hydrogels that act as bioresponsive, bactericidal materials. This systematic review covers recent advances in the development of supramolecular antimicrobial peptide technologies and discusses their potential impact on future drug discovery e_orts.

Original languageEnglish (US)
Article number2751
JournalMolecules
Volume25
Issue number12
DOIs
StatePublished - Jun 2020

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Simonson, A. W., Aronson, M. R., Medina, S. H., & Medina, S. H. (2020). Antimicrobial Scaffolds. Molecules, 25(12), [2751]. https://doi.org/10.3390/molecules25122751