Antinociceptive properties of tiletamine-zolazepam improved by addition of xylazine or butorphanol

Ronald Wilson, Ian Zagon, David R. Larach, C. Max Lang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A combination of tiletamine HCl and zolazepam HCl is frequently used as an anesthetic, but little is known about the antinociceptive properties of tiletamine-zolazepam. The antinociceptive properties of tiletamine-zolazepam alone or combined with xylazine or butorphanol were determined in the adult male rate using the tail-flick test. Changes in tail-flick latency were determined at 15, 45, and 75 min after IP drug administration of sterile water, sodium pentobarbital, morphine, tiletamine-zolazepam, xylazine, butorphanol, and tiletamine-zolazepam plus xylazine or butorphanol. Tail-flick latency approximated 100% maximum possible effect (MPE) at 15-75 min postinjection in morphine-treated rats. Tiletamine-zolazepam, xylazine, and butorphanol alone, at any dose utilized, produced less than 50% MPE. However, the combination of tiletamine-zolazepam with butorphanol or xylazine increased tail-flick latency approximately three times greater than tiletamine-zolazepam alone. These results demonstrate that: a) consonant with earlier findings, analgesia and anesthesia are independent states; b) tiletamine-zolazepam is not an effective combination with respect to analgesia; but c) in concert with appropriate drugs, it can exhibit potent antinociceptive properties.

Original languageEnglish (US)
Pages (from-to)1129-1133
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume43
Issue number4
DOIs
StatePublished - Jan 1 1992

Fingerprint

Butorphanol
Xylazine
Tail
Morphine
Zolazepam
Tiletamine
Anesthesia and Analgesia
zolazepam drug combination tiletamine
Pentobarbital
Pharmaceutical Preparations
Anesthetics
Rats
Analgesia
Water

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

@article{32bc3758d33f438c93f66bee7bf5d169,
title = "Antinociceptive properties of tiletamine-zolazepam improved by addition of xylazine or butorphanol",
abstract = "A combination of tiletamine HCl and zolazepam HCl is frequently used as an anesthetic, but little is known about the antinociceptive properties of tiletamine-zolazepam. The antinociceptive properties of tiletamine-zolazepam alone or combined with xylazine or butorphanol were determined in the adult male rate using the tail-flick test. Changes in tail-flick latency were determined at 15, 45, and 75 min after IP drug administration of sterile water, sodium pentobarbital, morphine, tiletamine-zolazepam, xylazine, butorphanol, and tiletamine-zolazepam plus xylazine or butorphanol. Tail-flick latency approximated 100{\%} maximum possible effect (MPE) at 15-75 min postinjection in morphine-treated rats. Tiletamine-zolazepam, xylazine, and butorphanol alone, at any dose utilized, produced less than 50{\%} MPE. However, the combination of tiletamine-zolazepam with butorphanol or xylazine increased tail-flick latency approximately three times greater than tiletamine-zolazepam alone. These results demonstrate that: a) consonant with earlier findings, analgesia and anesthesia are independent states; b) tiletamine-zolazepam is not an effective combination with respect to analgesia; but c) in concert with appropriate drugs, it can exhibit potent antinociceptive properties.",
author = "Ronald Wilson and Ian Zagon and Larach, {David R.} and Lang, {C. Max}",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/0091-3057(92)90492-X",
language = "English (US)",
volume = "43",
pages = "1129--1133",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",

}

Antinociceptive properties of tiletamine-zolazepam improved by addition of xylazine or butorphanol. / Wilson, Ronald; Zagon, Ian; Larach, David R.; Lang, C. Max.

In: Pharmacology, Biochemistry and Behavior, Vol. 43, No. 4, 01.01.1992, p. 1129-1133.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antinociceptive properties of tiletamine-zolazepam improved by addition of xylazine or butorphanol

AU - Wilson, Ronald

AU - Zagon, Ian

AU - Larach, David R.

AU - Lang, C. Max

PY - 1992/1/1

Y1 - 1992/1/1

N2 - A combination of tiletamine HCl and zolazepam HCl is frequently used as an anesthetic, but little is known about the antinociceptive properties of tiletamine-zolazepam. The antinociceptive properties of tiletamine-zolazepam alone or combined with xylazine or butorphanol were determined in the adult male rate using the tail-flick test. Changes in tail-flick latency were determined at 15, 45, and 75 min after IP drug administration of sterile water, sodium pentobarbital, morphine, tiletamine-zolazepam, xylazine, butorphanol, and tiletamine-zolazepam plus xylazine or butorphanol. Tail-flick latency approximated 100% maximum possible effect (MPE) at 15-75 min postinjection in morphine-treated rats. Tiletamine-zolazepam, xylazine, and butorphanol alone, at any dose utilized, produced less than 50% MPE. However, the combination of tiletamine-zolazepam with butorphanol or xylazine increased tail-flick latency approximately three times greater than tiletamine-zolazepam alone. These results demonstrate that: a) consonant with earlier findings, analgesia and anesthesia are independent states; b) tiletamine-zolazepam is not an effective combination with respect to analgesia; but c) in concert with appropriate drugs, it can exhibit potent antinociceptive properties.

AB - A combination of tiletamine HCl and zolazepam HCl is frequently used as an anesthetic, but little is known about the antinociceptive properties of tiletamine-zolazepam. The antinociceptive properties of tiletamine-zolazepam alone or combined with xylazine or butorphanol were determined in the adult male rate using the tail-flick test. Changes in tail-flick latency were determined at 15, 45, and 75 min after IP drug administration of sterile water, sodium pentobarbital, morphine, tiletamine-zolazepam, xylazine, butorphanol, and tiletamine-zolazepam plus xylazine or butorphanol. Tail-flick latency approximated 100% maximum possible effect (MPE) at 15-75 min postinjection in morphine-treated rats. Tiletamine-zolazepam, xylazine, and butorphanol alone, at any dose utilized, produced less than 50% MPE. However, the combination of tiletamine-zolazepam with butorphanol or xylazine increased tail-flick latency approximately three times greater than tiletamine-zolazepam alone. These results demonstrate that: a) consonant with earlier findings, analgesia and anesthesia are independent states; b) tiletamine-zolazepam is not an effective combination with respect to analgesia; but c) in concert with appropriate drugs, it can exhibit potent antinociceptive properties.

UR - http://www.scopus.com/inward/record.url?scp=0026439383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026439383&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(92)90492-X

DO - 10.1016/0091-3057(92)90492-X

M3 - Article

C2 - 1475295

AN - SCOPUS:0026439383

VL - 43

SP - 1129

EP - 1133

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 4

ER -