Antiplasmodial and antiproliferative pseudoguaianolides of Athroisma proteiforme from the Madagascar dry forest (1)

Ende Pan, Alexander P. Gorka, John N. Alumasa, Carla Slebodnick, Liva Harinantenaina, Peggy J. Brodie, Paul D. Roepe, Richard Randrianaivo, Chris Birkinshaw, David G.I. Kingston

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13 Scopus citations

Abstract

Investigation of extracts from the plant Athroisma proteiforme (Humbert) Mattf. (Asteraceae) for antimalarial activity led to the isolation of the five new sesquiterpene lactones 1-5 together with centaureidin (6). The structures of the new compounds were deduced from analyses of physical and spectroscopic data, and the absolute configuration of compound 1 was confirmed by an X-ray crystallographic study. Athrolides C (3) and D (4) both showed antiplasmodial activities with IC 50 values of 6.6 (3) and 7.2 μM (4) against the HB3 strain and 5.5 (3) and 4.2 μM (4) against the Dd2 strain of the malarial parasite Plasmodium falciparum. The isolates 1-6 also showed antiproliferative activity against A2780 human ovarian cancer cells, with IC 50 values ranging from 0.4 to 2.5 μM.

Original languageEnglish (US)
Pages (from-to)2174-2180
Number of pages7
JournalJournal of Natural Products
Volume74
Issue number10
DOIs
StatePublished - Oct 28 2011

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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