Antitumour agents synthesized from K2PtCl4 and polymeric or cyclic phosphazenes

Harry R. Allcock, R. W. Allen, J. P. O'Brien

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The phosphazenes [NP(NHMe)2]n, [NP(NHMe) 2]4, and [NPMe2]4, react with K 2PtCl4 in organic media to yield square-planar Pt complexes of the type (NPR2)x PtCl2, and in aqueous acid media to yield salts of the type, [H2N4P 4R8]2+[PtCl4]2-; moreover, these compounds have shown significant antitumour behaviour in preliminary testing.

Original languageEnglish (US)
Pages (from-to)717-718
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number18
DOIs
StatePublished - Dec 1 1976

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Antineoplastic Agents
Salts
Acids
Testing
platinum tetrachloride

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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abstract = "The phosphazenes [NP(NHMe)2]n, [NP(NHMe) 2]4, and [NPMe2]4, react with K 2PtCl4 in organic media to yield square-planar Pt complexes of the type (NPR2)x PtCl2, and in aqueous acid media to yield salts of the type, [H2N4P 4R8]2+[PtCl4]2-; moreover, these compounds have shown significant antitumour behaviour in preliminary testing.",
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Antitumour agents synthesized from K2PtCl4 and polymeric or cyclic phosphazenes. / Allcock, Harry R.; Allen, R. W.; O'Brien, J. P.

In: Journal of the Chemical Society, Chemical Communications, No. 18, 01.12.1976, p. 717-718.

Research output: Contribution to journalArticle

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AU - O'Brien, J. P.

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N2 - The phosphazenes [NP(NHMe)2]n, [NP(NHMe) 2]4, and [NPMe2]4, react with K 2PtCl4 in organic media to yield square-planar Pt complexes of the type (NPR2)x PtCl2, and in aqueous acid media to yield salts of the type, [H2N4P 4R8]2+[PtCl4]2-; moreover, these compounds have shown significant antitumour behaviour in preliminary testing.

AB - The phosphazenes [NP(NHMe)2]n, [NP(NHMe) 2]4, and [NPMe2]4, react with K 2PtCl4 in organic media to yield square-planar Pt complexes of the type (NPR2)x PtCl2, and in aqueous acid media to yield salts of the type, [H2N4P 4R8]2+[PtCl4]2-; moreover, these compounds have shown significant antitumour behaviour in preliminary testing.

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