@article{1585e7df1a1440d5813c74f6fcc5e9ff,
title = "Antitumour agents synthesized from K2PtCl4 and polymeric or cyclic phosphazenes",
abstract = "The phosphazenes [NP(NHMe)2]n, [NP(NHMe) 2]4, and [NPMe2]4, react with K 2PtCl4 in organic media to yield square-planar Pt complexes of the type (NPR2)x PtCl2, and in aqueous acid media to yield salts of the type, [H2N4P 4R8]2+[PtCl4]2-; moreover, these compounds have shown significant antitumour behaviour in preliminary testing.",
author = "Allcock, {H. R.} and Allen, {R. W.} and O'Brien, {J. P.}",
note = "Funding Information: Both compounds were active in the Erlich Ascites screening test (78 and 91% inhibition, respectively). This, to our knowledge, is the first time that a charged platinum complex has been shown to display antitumour activity. This work was supported in part by the U.S. Army Research Office. (Received, 14th June 1976; Corn. 667.) -f A high activity was shown against P388 lymphocytic leukaemia (max T/C = 130) and against Ehrlich Ascites mouse tumours (86% inhibition). The P388 lymphocytic leukaemia tests were conducted by National Institutes of Health, Division of Cancer Treatment (a T/Cvalue over 125 is considered to be significant), and the Ehrlich Ascites inhibition tests were carried out by Dr. Iris H. Hall, Division of Medicinal Chemistry, University of North Carolina. 9 Crystal data: monoclinic cell, a = 10.351, b = 15.619, c = 14.327, fl = 92.385, space group P2,/n, 2 = 4. The structure was refined to an R factor of 0,049. The details of this structure will be published elsewhere. 7 A maximum T/C of 127 was found in the P388 survival test and a 61 % inhibition in the Ehrlich Ascites screen. 1 B, Rosenberg, L. Van Camp, J. E. Trosko, and V. H. Mansour, Nature, 1969, 222, 385. 2 H. R. Allcock, W. J. Cook, and D. P. Mack, Inorg. Chem., 1972, 11, 2584.",
year = "1976",
doi = "10.1039/C39760000717",
language = "English (US)",
pages = "717--718",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "18",
}