Apolipoprotein E and dementia in Parkinson disease

A meta-analysis

Xuemei Huang, Peter Chen, Daniel I. Kaufer, Alexander I. Tröster, Charles Poole

Research output: Contribution to journalReview article

91 Citations (Scopus)

Abstract

Objective: To understand the relationship of apolipoprotein E (APOE) polymorphism to dementia in Parkinson disease (PD) because the APOE ε4 allele is linked to Alzheimer disease. Data Source: We reviewed MEDLINE, BIOSIS Previews, and ISI Web of Science from January 1, 1966, to May 7, 2004, supplemented by citation analysis from retrieved articles. Study Selection: Case-control studies using clinical or pathologic criteria for PD and dementia, and with complete APOE genotype frequencies data. Data Extraction: We compared estimated prevalence odds ratios for dementia in PD in relation to each allele. We also looked for evidence of heterogeneity and publication bias and performed a stratified analysis on several study characteristics. Data Synthesis: Data analyses suggest publication bias and heterogeneity of source data for the ε4 allele (homogeneity P=.2; Begg and Mazumdar, P=.06; and Egger et al, P=.1). The estimated odds ratios for development of dementia in PD are 1.6 for ε4 (95% confidence interval, 1.0-2.5); 1.3 for ε2 (95% confidence interval, 0.73-2.4); and 0.54 for ε3 (95% confidence interval, 0.18-1.6). The odds ratio estimates for ε4 were higher for studies published in 1996 or later (2.3 vs 1.0) and for studies conducted outside North American sites (2.4 vs 1.2). Conclusions: The APOE aε4 allele appears to be associated with a higher prevalence of dementia in PD. Publication bias and heterogeneous source data may, however, confound this conclusion. Confirmatory studies that use standardized and validated diagnostic criteria for dementia in PD are needed.

Original languageEnglish (US)
Pages (from-to)189-193
Number of pages5
JournalArchives of Neurology
Volume63
Issue number2
DOIs
StatePublished - Feb 1 2006

Fingerprint

Apolipoproteins E
Parkinson Disease
Dementia
Meta-Analysis
Publication Bias
Information Storage and Retrieval
Alleles
Odds Ratio
Confidence Intervals
Apolipoprotein E4
MEDLINE
Meta-analysis
Parkinson's Disease
Case-Control Studies
Alzheimer Disease
Genotype
Allele
Confidence Interval

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Huang, Xuemei ; Chen, Peter ; Kaufer, Daniel I. ; Tröster, Alexander I. ; Poole, Charles. / Apolipoprotein E and dementia in Parkinson disease : A meta-analysis. In: Archives of Neurology. 2006 ; Vol. 63, No. 2. pp. 189-193.
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Apolipoprotein E and dementia in Parkinson disease : A meta-analysis. / Huang, Xuemei; Chen, Peter; Kaufer, Daniel I.; Tröster, Alexander I.; Poole, Charles.

In: Archives of Neurology, Vol. 63, No. 2, 01.02.2006, p. 189-193.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Apolipoprotein E and dementia in Parkinson disease

T2 - A meta-analysis

AU - Huang, Xuemei

AU - Chen, Peter

AU - Kaufer, Daniel I.

AU - Tröster, Alexander I.

AU - Poole, Charles

PY - 2006/2/1

Y1 - 2006/2/1

N2 - Objective: To understand the relationship of apolipoprotein E (APOE) polymorphism to dementia in Parkinson disease (PD) because the APOE ε4 allele is linked to Alzheimer disease. Data Source: We reviewed MEDLINE, BIOSIS Previews, and ISI Web of Science from January 1, 1966, to May 7, 2004, supplemented by citation analysis from retrieved articles. Study Selection: Case-control studies using clinical or pathologic criteria for PD and dementia, and with complete APOE genotype frequencies data. Data Extraction: We compared estimated prevalence odds ratios for dementia in PD in relation to each allele. We also looked for evidence of heterogeneity and publication bias and performed a stratified analysis on several study characteristics. Data Synthesis: Data analyses suggest publication bias and heterogeneity of source data for the ε4 allele (homogeneity P=.2; Begg and Mazumdar, P=.06; and Egger et al, P=.1). The estimated odds ratios for development of dementia in PD are 1.6 for ε4 (95% confidence interval, 1.0-2.5); 1.3 for ε2 (95% confidence interval, 0.73-2.4); and 0.54 for ε3 (95% confidence interval, 0.18-1.6). The odds ratio estimates for ε4 were higher for studies published in 1996 or later (2.3 vs 1.0) and for studies conducted outside North American sites (2.4 vs 1.2). Conclusions: The APOE aε4 allele appears to be associated with a higher prevalence of dementia in PD. Publication bias and heterogeneous source data may, however, confound this conclusion. Confirmatory studies that use standardized and validated diagnostic criteria for dementia in PD are needed.

AB - Objective: To understand the relationship of apolipoprotein E (APOE) polymorphism to dementia in Parkinson disease (PD) because the APOE ε4 allele is linked to Alzheimer disease. Data Source: We reviewed MEDLINE, BIOSIS Previews, and ISI Web of Science from January 1, 1966, to May 7, 2004, supplemented by citation analysis from retrieved articles. Study Selection: Case-control studies using clinical or pathologic criteria for PD and dementia, and with complete APOE genotype frequencies data. Data Extraction: We compared estimated prevalence odds ratios for dementia in PD in relation to each allele. We also looked for evidence of heterogeneity and publication bias and performed a stratified analysis on several study characteristics. Data Synthesis: Data analyses suggest publication bias and heterogeneity of source data for the ε4 allele (homogeneity P=.2; Begg and Mazumdar, P=.06; and Egger et al, P=.1). The estimated odds ratios for development of dementia in PD are 1.6 for ε4 (95% confidence interval, 1.0-2.5); 1.3 for ε2 (95% confidence interval, 0.73-2.4); and 0.54 for ε3 (95% confidence interval, 0.18-1.6). The odds ratio estimates for ε4 were higher for studies published in 1996 or later (2.3 vs 1.0) and for studies conducted outside North American sites (2.4 vs 1.2). Conclusions: The APOE aε4 allele appears to be associated with a higher prevalence of dementia in PD. Publication bias and heterogeneous source data may, however, confound this conclusion. Confirmatory studies that use standardized and validated diagnostic criteria for dementia in PD are needed.

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U2 - 10.1001/archneur.63.2.189

DO - 10.1001/archneur.63.2.189

M3 - Review article

VL - 63

SP - 189

EP - 193

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

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