Apolipoprotein e (APOE) ε4 allele is associated with increased symptom reporting following sports concussion

Victoria C. Merritt, Peter A. Arnett

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Exploring the relationship between genetic factors and outcome following brain injury has received increased attention in recent years. However, few studies have evaluated the influence of genes on specific sequelae of concussion. The purpose of this study was to determine how the ε4 allele of the apolipoprotein E (APOE) gene influences symptom expression following sports-related concussion. Participants included 42 collegiate athletes who underwent neuropsychological testing, including completion of the Post-Concussion Symptom Scale (PCSS), within 3 months after sustaining a concussion (73.8% were evaluated within 1 week). Athletes provided buccal samples that were analyzed to determine the make-up of their APOE genotype. Dependent variables included a total symptom score and four symptom clusters derived from the PCSS. Mann-Whitney U tests showed higher scores reported by athletes with the ε4 allele compared to those without it on the total symptom score and the physical and cognitive symptom clusters. Furthermore, logistic regression showed that the ε4 allele independently predicted those athletes who reported physical and cognitive symptoms following concussion. These findings illustrate that ε4+ athletes report greater symptomatology post-concussion than ε4- athletes, suggesting that the ε4 genotype may confer risk for poorer post-concussion outcome. (JINS, 2016, 22, 89-94)

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalJournal of the International Neuropsychological Society
Volume22
Issue number1
DOIs
StatePublished - Nov 17 2015

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Apolipoproteins
Athletes
Sports
Alleles
Post-Concussion Syndrome
Neurobehavioral Manifestations
Genotype
Apolipoprotein E4
Cheek
Nonparametric Statistics
Brain Injuries
Genes
Logistic Models

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

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