Apoptosis: Molecules and mechanisms

Marina Konopleva, Shourong Zhao, Zhong Xie, Harry Segall, Anas Younes, David F. Claxton, Zeev Estrov, Steven M. Kornblau, Michael Andreeff

Research output: Contribution to journalArticlepeer-review

122 Scopus citations

Abstract

This review of the molecules and pathways involved in programmed cell death (apoptosis) discriminates triggers of apoptosis (e.g. chemotherapy, radiation, Fas ligation), modulators of apoptosis (e.g. Bcl-2 family members, Bcl-2 interacting proteins, Apafs, IAPs, and Fas/FasL modulators including FLICE and FLIPs), effectors (caspases 1-13) and cleavage substrates (e.g. PARP). Special consideration is given to the structure-function relationship of Bcl-2 family members and to their post-transcriptional modification. Brief references are made to the role of apoptotic pathway in leukemias and lymphomas and to strategies of modulating apoptotic pathways.

Original languageEnglish (US)
Pages (from-to)217-236
Number of pages20
JournalAdvances in experimental medicine and biology
Volume457
DOIs
StatePublished - 1999

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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