Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs

Joshua E. Allen, Bikramajit Singh Saroya, Miriam Kunkel, David T. Dicker, Avisnata Das, Kristi L. Peters, Jamal Joudeh, Junjia Zhu, Wafik S. El-Deiry

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Enumeration of circulating tumor cells (CTCs) by the CellSearch system provides prognostic information in metastatic colorectal cancer, regardless of metastatic site. We found that CTCs generally represent >1% of observed events with CellSearch analysis and adapted scoring criteria to classify other peripheral blood events. Examination of twenty two metastatic colorectal cancer patients' blood revealed that patients with high CEA or liver metastases, but not lung or distant lymph node metastases, possessed significant numbers of apoptotic CTCs prior to treatment initiation by Fischer's exact test. Six out of eleven patients with liver metastasis possessed apoptotic CTCs whereas one of nine patients with other metastases had measurable apoptotic CTCs. An elevated CTC number was not necessarily associated with apoptotic CTCs or CTC debris by Spearman's correlation, suggesting the metastatic site rather than CTCs per se as contributing to the origin of these events.

Original languageEnglish (US)
Pages (from-to)1753-1760
Number of pages8
JournalOncotarget
Volume5
Issue number7
DOIs
StatePublished - Jan 1 2014

Fingerprint

Circulating Neoplastic Cells
Colorectal Neoplasms
Neoplasm Metastasis
Liver
Cell Count
Lymph Nodes
Lung

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Allen, Joshua E. ; Saroya, Bikramajit Singh ; Kunkel, Miriam ; Dicker, David T. ; Das, Avisnata ; Peters, Kristi L. ; Joudeh, Jamal ; Zhu, Junjia ; El-Deiry, Wafik S. / Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs. In: Oncotarget. 2014 ; Vol. 5, No. 7. pp. 1753-1760.
@article{0f4eec3cbcac4a1490bdc47d1ba3346e,
title = "Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs",
abstract = "Enumeration of circulating tumor cells (CTCs) by the CellSearch system provides prognostic information in metastatic colorectal cancer, regardless of metastatic site. We found that CTCs generally represent >1{\%} of observed events with CellSearch analysis and adapted scoring criteria to classify other peripheral blood events. Examination of twenty two metastatic colorectal cancer patients' blood revealed that patients with high CEA or liver metastases, but not lung or distant lymph node metastases, possessed significant numbers of apoptotic CTCs prior to treatment initiation by Fischer's exact test. Six out of eleven patients with liver metastasis possessed apoptotic CTCs whereas one of nine patients with other metastases had measurable apoptotic CTCs. An elevated CTC number was not necessarily associated with apoptotic CTCs or CTC debris by Spearman's correlation, suggesting the metastatic site rather than CTCs per se as contributing to the origin of these events.",
author = "Allen, {Joshua E.} and Saroya, {Bikramajit Singh} and Miriam Kunkel and Dicker, {David T.} and Avisnata Das and Peters, {Kristi L.} and Jamal Joudeh and Junjia Zhu and El-Deiry, {Wafik S.}",
year = "2014",
month = "1",
day = "1",
doi = "10.18632/oncotarget.1524",
language = "English (US)",
volume = "5",
pages = "1753--1760",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",
number = "7",

}

Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs. / Allen, Joshua E.; Saroya, Bikramajit Singh; Kunkel, Miriam; Dicker, David T.; Das, Avisnata; Peters, Kristi L.; Joudeh, Jamal; Zhu, Junjia; El-Deiry, Wafik S.

In: Oncotarget, Vol. 5, No. 7, 01.01.2014, p. 1753-1760.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs

AU - Allen, Joshua E.

AU - Saroya, Bikramajit Singh

AU - Kunkel, Miriam

AU - Dicker, David T.

AU - Das, Avisnata

AU - Peters, Kristi L.

AU - Joudeh, Jamal

AU - Zhu, Junjia

AU - El-Deiry, Wafik S.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Enumeration of circulating tumor cells (CTCs) by the CellSearch system provides prognostic information in metastatic colorectal cancer, regardless of metastatic site. We found that CTCs generally represent >1% of observed events with CellSearch analysis and adapted scoring criteria to classify other peripheral blood events. Examination of twenty two metastatic colorectal cancer patients' blood revealed that patients with high CEA or liver metastases, but not lung or distant lymph node metastases, possessed significant numbers of apoptotic CTCs prior to treatment initiation by Fischer's exact test. Six out of eleven patients with liver metastasis possessed apoptotic CTCs whereas one of nine patients with other metastases had measurable apoptotic CTCs. An elevated CTC number was not necessarily associated with apoptotic CTCs or CTC debris by Spearman's correlation, suggesting the metastatic site rather than CTCs per se as contributing to the origin of these events.

AB - Enumeration of circulating tumor cells (CTCs) by the CellSearch system provides prognostic information in metastatic colorectal cancer, regardless of metastatic site. We found that CTCs generally represent >1% of observed events with CellSearch analysis and adapted scoring criteria to classify other peripheral blood events. Examination of twenty two metastatic colorectal cancer patients' blood revealed that patients with high CEA or liver metastases, but not lung or distant lymph node metastases, possessed significant numbers of apoptotic CTCs prior to treatment initiation by Fischer's exact test. Six out of eleven patients with liver metastasis possessed apoptotic CTCs whereas one of nine patients with other metastases had measurable apoptotic CTCs. An elevated CTC number was not necessarily associated with apoptotic CTCs or CTC debris by Spearman's correlation, suggesting the metastatic site rather than CTCs per se as contributing to the origin of these events.

UR - http://www.scopus.com/inward/record.url?scp=84898987182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898987182&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.1524

DO - 10.18632/oncotarget.1524

M3 - Article

C2 - 24334302

AN - SCOPUS:84898987182

VL - 5

SP - 1753

EP - 1760

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 7

ER -