TY - JOUR
T1 - Apparent serotonergic modulation of the dose-dependent biphasic response of neostriatal neurons produced by d-amphetamine
AU - Rebec, George V.
AU - Alloway, Kevin D.
AU - Curtis, Stephen D.
N1 - Funding Information:
This research was supported, in part, by USPHS Grant DA-02451-02 awarded to G.V.R. We wish to thank Dr. R. Mark Wightman for helpful advice and assistance in setting up our LCEC system. We also acknowledge the help of Ms. Doris Harris for preparing the histological sections and Ms. Suzanne Hull for preparing the illustrations.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1981/4/6
Y1 - 1981/4/6
N2 - Previous reports indicate that amphetamine produces a dose-dependent shift in the firing rate of neurons in the anterior neostriatum that parallels the shift in behavior from locomotion to focused stereotypy. To determine if para-chlorophenylalanine (PCPA), which alters the pattern of the behavioral response to amphetamine, also changes the pattern of the neuronal response to the drug, a dose-response analysis was performed on amphetamine-induced changes in unit activity in the anterior neostriatum of rats pretreated 48 h previously with 300 mg/kg PCPA or vehicle. An intraperitoneal injection of 1.0 mg/kg d-amphetamine, which inhibited neostriatal activity in vehicle controls, produced in PCPA-pretreated animals a prolonged excitation. In contrast, the pronounced increase in firing rate produced by 7.5 mg/kg d-amphetamine in control rats was significantly reduced following PCPA pretreatment. Liquid chromatograhy with electrochemical detection revealed that compared to controls, PCPA produced a significant reduction of serotonin, but not dopamine or norepinephrine, in the telencephalon. The differential effects of PCPA on the action of low and high doses of d-amphetamine in the anterior neostriatum may explain the differential influence of serotonergic systems on amphetamine-induced locomotion and stereotypy.
AB - Previous reports indicate that amphetamine produces a dose-dependent shift in the firing rate of neurons in the anterior neostriatum that parallels the shift in behavior from locomotion to focused stereotypy. To determine if para-chlorophenylalanine (PCPA), which alters the pattern of the behavioral response to amphetamine, also changes the pattern of the neuronal response to the drug, a dose-response analysis was performed on amphetamine-induced changes in unit activity in the anterior neostriatum of rats pretreated 48 h previously with 300 mg/kg PCPA or vehicle. An intraperitoneal injection of 1.0 mg/kg d-amphetamine, which inhibited neostriatal activity in vehicle controls, produced in PCPA-pretreated animals a prolonged excitation. In contrast, the pronounced increase in firing rate produced by 7.5 mg/kg d-amphetamine in control rats was significantly reduced following PCPA pretreatment. Liquid chromatograhy with electrochemical detection revealed that compared to controls, PCPA produced a significant reduction of serotonin, but not dopamine or norepinephrine, in the telencephalon. The differential effects of PCPA on the action of low and high doses of d-amphetamine in the anterior neostriatum may explain the differential influence of serotonergic systems on amphetamine-induced locomotion and stereotypy.
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U2 - 10.1016/0006-8993(81)90901-X
DO - 10.1016/0006-8993(81)90901-X
M3 - Article
C2 - 6452929
AN - SCOPUS:0019412356
VL - 210
SP - 277
EP - 289
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -