Rathke's pouch cysts are uncommonly found on imaging and are usually incidental in nature. Herein, we report a most unusual case of Rathke's pouch cyst verified to have resolved and then 20 years later, to have returned. The germane literature regarding such a phenomenon is reviewed. We believe this to be the first report of a patient with an appearing, disappearing, and reappearing Rathke's cleft cyst.
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