Application of creeping flow through a linearly absorbing slit filled with porous medium to diseased renal tubules

A. M. Siddiqui, Q. A. Azim, D. A. Sunny

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper, we have discussed the flow of a Newtonian fluid through a slit filled with porous medium and linearly reabsorbing porous walls. The study is motivated by fluid flow in diseased renal tubules in a kidney. Due to diseases, some fibrous material, fatty substances and solid waste particles, etc., may get suspended in tubule channel as well as on the pores of the wall, resulting in the porous filling in the slit and biofouling, respectively. In this study, the absorption at the wall is assumed to follow a linear pattern and the fluid is assumed to be entering the channel at a prescribed initial flow rate. The problem of the two-dimensional fluid flow is formulated using stream function, and inverse solution method is applied to obtain an exact solution of the fourth-order compatibility equation. Some special cases are also deduced from the obtained results and compared with available results from literature. Expressions for various physically relevant quantities like fluid velocities, volume flow rate, fractional reabsorption, leakage flux and pressure distribution are obtained. The results are used to demonstrate how medium porosity and biofouling parameter may affect average pressure differences in the renal tubules of a rat kidney. Finally, the results are presented graphically and effects of changing various parameters on the flow are analysed. We have also deduced some special cases when the wall reabsorption is uniform, and when there is no medium porosity. We have shown these special cases match with the already present results in the literature.

Original languageEnglish (US)
Pages (from-to)569-584
Number of pages16
JournalBiomechanics and Modeling in Mechanobiology
Volume20
Issue number2
DOIs
StatePublished - Apr 2021

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Modeling and Simulation
  • Mechanical Engineering

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