Application of non-myeloablative allogeneic stem cell transplantation to solid tumors

Research output: Contribution to journalArticle

Abstract

In contrast to conventional stem cell transplantation which utilizes high-dose chemotherapy and/or total body irradiation as a conditioning regimen, non-myeloablative stem cell transplantation (NST) uses mainly immunosuppressants. NST is now being used to treat solid tumors, as it greatly alleviates regimen-related toxicity. NST, which utilizes the graft-versus-tumor effect as an anti-tumor weapon, is considered to be one type of immunotherapy. Ongoing clinical studies in the U.S. and Europe as well as in Japan are producing promising results for renal cell carcinoma and other tumors.

Original languageEnglish (US)
Pages (from-to)461-466
Number of pages6
JournalBiotherapy
Volume15
Issue number4
StatePublished - 2001

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Stem Cell Transplantation
Neoplasms
Weapons
Whole-Body Irradiation
Immunosuppressive Agents
Renal Cell Carcinoma
Immunotherapy
Japan
Transplants
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Immunology and Allergy

Cite this

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abstract = "In contrast to conventional stem cell transplantation which utilizes high-dose chemotherapy and/or total body irradiation as a conditioning regimen, non-myeloablative stem cell transplantation (NST) uses mainly immunosuppressants. NST is now being used to treat solid tumors, as it greatly alleviates regimen-related toxicity. NST, which utilizes the graft-versus-tumor effect as an anti-tumor weapon, is considered to be one type of immunotherapy. Ongoing clinical studies in the U.S. and Europe as well as in Japan are producing promising results for renal cell carcinoma and other tumors.",
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Application of non-myeloablative allogeneic stem cell transplantation to solid tumors. / Mineishi, Shin.

In: Biotherapy, Vol. 15, No. 4, 2001, p. 461-466.

Research output: Contribution to journalArticle

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