Application of speckle-tracking in the evaluation of carotid artery function in subjects with hypertension and diabetes

Eric Y. Yang, Gerd Brunner, Hisham Dokainish, Craig J. Hartley, George Taffet, Nasser Lakkis, Addison A. Taylor, Arunima Misra, Marti L. McCulloch, Joel D. Morrisett, Salim S. Virani, Christie M. Ballantyne, Sherif F. Nagueh, Vijay Nambi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Speckle-tracking enables direct tracking of carotid arterial wall motion. Timing intervals determined with carotid speckle-tracking and slopes calculated from carotid artery area versus cardiac cycle curves may provide further information on arterial function and stiffness. The proposed arterial stiffness parameters were examined in healthy controls (n = 20), nondiabetic patients with hypertension (n = 20), and patients with type 2 diabetes (n = 21). Methods: Bilateral electrocardiographically gated ultrasonograms of the distal common carotid artery were acquired using a 12-MHz vascular probe. Four timing intervals were derived from speckle-tracked carotid arterial strain curves: (1) carotid predistension period, (2) peak carotid arterial strain time, (3) arterial distension period, and (4) arterial diastolic time. In addition, carotid artery area curves were recorded over the cardiac cycle and subdivided into four segments, S1 to S4, relating to arterial distention and contraction periods. Results: Mean far wall predistension period and peak carotid arterial strain time were more delayed in patients with diabetes and hypertension than in controls. Global mean arterial distension period was prolonged and arterial diastolic time was shorter in patients with hypertension and diabetes than in controls. Slopes of segments S2 and S4 were markedly steeper in the combined group of patients with hypertension and diabetes compared with healthy controls (P =.03 and P =.02, respectively). Conclusions: Speckle-tracking-based measures of arterial stiffness may provide potential additive value in assessing vascular function in patients at risk for cardiovascular disease.

Original languageEnglish (US)
JournalJournal of the American Society of Echocardiography
Volume26
Issue number8
DOIs
StatePublished - Jan 1 2013

Fingerprint

Carotid Arteries
Hypertension
Vascular Stiffness
Blood Vessels
Common Carotid Artery
Type 2 Diabetes Mellitus
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Yang, Eric Y. ; Brunner, Gerd ; Dokainish, Hisham ; Hartley, Craig J. ; Taffet, George ; Lakkis, Nasser ; Taylor, Addison A. ; Misra, Arunima ; McCulloch, Marti L. ; Morrisett, Joel D. ; Virani, Salim S. ; Ballantyne, Christie M. ; Nagueh, Sherif F. ; Nambi, Vijay. / Application of speckle-tracking in the evaluation of carotid artery function in subjects with hypertension and diabetes. In: Journal of the American Society of Echocardiography. 2013 ; Vol. 26, No. 8.
@article{ed8a237b1222479e873fb31db61abfc4,
title = "Application of speckle-tracking in the evaluation of carotid artery function in subjects with hypertension and diabetes",
abstract = "Background: Speckle-tracking enables direct tracking of carotid arterial wall motion. Timing intervals determined with carotid speckle-tracking and slopes calculated from carotid artery area versus cardiac cycle curves may provide further information on arterial function and stiffness. The proposed arterial stiffness parameters were examined in healthy controls (n = 20), nondiabetic patients with hypertension (n = 20), and patients with type 2 diabetes (n = 21). Methods: Bilateral electrocardiographically gated ultrasonograms of the distal common carotid artery were acquired using a 12-MHz vascular probe. Four timing intervals were derived from speckle-tracked carotid arterial strain curves: (1) carotid predistension period, (2) peak carotid arterial strain time, (3) arterial distension period, and (4) arterial diastolic time. In addition, carotid artery area curves were recorded over the cardiac cycle and subdivided into four segments, S1 to S4, relating to arterial distention and contraction periods. Results: Mean far wall predistension period and peak carotid arterial strain time were more delayed in patients with diabetes and hypertension than in controls. Global mean arterial distension period was prolonged and arterial diastolic time was shorter in patients with hypertension and diabetes than in controls. Slopes of segments S2 and S4 were markedly steeper in the combined group of patients with hypertension and diabetes compared with healthy controls (P =.03 and P =.02, respectively). Conclusions: Speckle-tracking-based measures of arterial stiffness may provide potential additive value in assessing vascular function in patients at risk for cardiovascular disease.",
author = "Yang, {Eric Y.} and Gerd Brunner and Hisham Dokainish and Hartley, {Craig J.} and George Taffet and Nasser Lakkis and Taylor, {Addison A.} and Arunima Misra and McCulloch, {Marti L.} and Morrisett, {Joel D.} and Virani, {Salim S.} and Ballantyne, {Christie M.} and Nagueh, {Sherif F.} and Vijay Nambi",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.echo.2013.04.014",
language = "English (US)",
volume = "26",
journal = "Journal of the American Society of Echocardiography",
issn = "0894-7317",
publisher = "Mosby Inc.",
number = "8",

}

Yang, EY, Brunner, G, Dokainish, H, Hartley, CJ, Taffet, G, Lakkis, N, Taylor, AA, Misra, A, McCulloch, ML, Morrisett, JD, Virani, SS, Ballantyne, CM, Nagueh, SF & Nambi, V 2013, 'Application of speckle-tracking in the evaluation of carotid artery function in subjects with hypertension and diabetes', Journal of the American Society of Echocardiography, vol. 26, no. 8. https://doi.org/10.1016/j.echo.2013.04.014

Application of speckle-tracking in the evaluation of carotid artery function in subjects with hypertension and diabetes. / Yang, Eric Y.; Brunner, Gerd; Dokainish, Hisham; Hartley, Craig J.; Taffet, George; Lakkis, Nasser; Taylor, Addison A.; Misra, Arunima; McCulloch, Marti L.; Morrisett, Joel D.; Virani, Salim S.; Ballantyne, Christie M.; Nagueh, Sherif F.; Nambi, Vijay.

In: Journal of the American Society of Echocardiography, Vol. 26, No. 8, 01.01.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Application of speckle-tracking in the evaluation of carotid artery function in subjects with hypertension and diabetes

AU - Yang, Eric Y.

AU - Brunner, Gerd

AU - Dokainish, Hisham

AU - Hartley, Craig J.

AU - Taffet, George

AU - Lakkis, Nasser

AU - Taylor, Addison A.

AU - Misra, Arunima

AU - McCulloch, Marti L.

AU - Morrisett, Joel D.

AU - Virani, Salim S.

AU - Ballantyne, Christie M.

AU - Nagueh, Sherif F.

AU - Nambi, Vijay

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: Speckle-tracking enables direct tracking of carotid arterial wall motion. Timing intervals determined with carotid speckle-tracking and slopes calculated from carotid artery area versus cardiac cycle curves may provide further information on arterial function and stiffness. The proposed arterial stiffness parameters were examined in healthy controls (n = 20), nondiabetic patients with hypertension (n = 20), and patients with type 2 diabetes (n = 21). Methods: Bilateral electrocardiographically gated ultrasonograms of the distal common carotid artery were acquired using a 12-MHz vascular probe. Four timing intervals were derived from speckle-tracked carotid arterial strain curves: (1) carotid predistension period, (2) peak carotid arterial strain time, (3) arterial distension period, and (4) arterial diastolic time. In addition, carotid artery area curves were recorded over the cardiac cycle and subdivided into four segments, S1 to S4, relating to arterial distention and contraction periods. Results: Mean far wall predistension period and peak carotid arterial strain time were more delayed in patients with diabetes and hypertension than in controls. Global mean arterial distension period was prolonged and arterial diastolic time was shorter in patients with hypertension and diabetes than in controls. Slopes of segments S2 and S4 were markedly steeper in the combined group of patients with hypertension and diabetes compared with healthy controls (P =.03 and P =.02, respectively). Conclusions: Speckle-tracking-based measures of arterial stiffness may provide potential additive value in assessing vascular function in patients at risk for cardiovascular disease.

AB - Background: Speckle-tracking enables direct tracking of carotid arterial wall motion. Timing intervals determined with carotid speckle-tracking and slopes calculated from carotid artery area versus cardiac cycle curves may provide further information on arterial function and stiffness. The proposed arterial stiffness parameters were examined in healthy controls (n = 20), nondiabetic patients with hypertension (n = 20), and patients with type 2 diabetes (n = 21). Methods: Bilateral electrocardiographically gated ultrasonograms of the distal common carotid artery were acquired using a 12-MHz vascular probe. Four timing intervals were derived from speckle-tracked carotid arterial strain curves: (1) carotid predistension period, (2) peak carotid arterial strain time, (3) arterial distension period, and (4) arterial diastolic time. In addition, carotid artery area curves were recorded over the cardiac cycle and subdivided into four segments, S1 to S4, relating to arterial distention and contraction periods. Results: Mean far wall predistension period and peak carotid arterial strain time were more delayed in patients with diabetes and hypertension than in controls. Global mean arterial distension period was prolonged and arterial diastolic time was shorter in patients with hypertension and diabetes than in controls. Slopes of segments S2 and S4 were markedly steeper in the combined group of patients with hypertension and diabetes compared with healthy controls (P =.03 and P =.02, respectively). Conclusions: Speckle-tracking-based measures of arterial stiffness may provide potential additive value in assessing vascular function in patients at risk for cardiovascular disease.

UR - http://www.scopus.com/inward/record.url?scp=84880963908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880963908&partnerID=8YFLogxK

U2 - 10.1016/j.echo.2013.04.014

DO - 10.1016/j.echo.2013.04.014

M3 - Article

VL - 26

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

SN - 0894-7317

IS - 8

ER -