Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA.

S. S. Hecht, S. G. Carmella, N. Trushin, Thomas Spratt, P. G. Foiles, D. Hoffmann

Research output: Contribution to journalArticle

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Abstract

The tobacco-specific, nicotine-derived nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) are among the most important carcinogens in tobacco and tobacco smoke. Treatment of Fischer 344 rats with these carcinogens resulted in alkylation of haemoglobin and DNA by the 4-(3-pyridyl)-4-oxobutyl group formed during their metabolism. This alkyl group can be detached from globin or DNA under mild hydrolytic conditions as 4-hydroxy-1-(3-pyridyl)-1-butanone, which appears to be a potentially useful dosimeter for human exposure to, and activation of, tobacco-specific nitrosamines.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalIARC scientific publications
Issue number89
StatePublished - Dec 1 1988

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Nitrosamines
Tobacco
Hemoglobins
N'-nitrosonornicotine
DNA
Carcinogens
Globins
Inbred F344 Rats
Alkylation
Nicotine
Smoke

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hecht, S. S. ; Carmella, S. G. ; Trushin, N. ; Spratt, Thomas ; Foiles, P. G. ; Hoffmann, D. / Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA. In: IARC scientific publications. 1988 ; No. 89. pp. 121-128.
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Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA. / Hecht, S. S.; Carmella, S. G.; Trushin, N.; Spratt, Thomas; Foiles, P. G.; Hoffmann, D.

In: IARC scientific publications, No. 89, 01.12.1988, p. 121-128.

Research output: Contribution to journalArticle

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AU - Hecht, S. S.

AU - Carmella, S. G.

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AU - Foiles, P. G.

AU - Hoffmann, D.

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