Appropriate and inappropriate use of dronedarone in 2013

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Opinion statement: Dronedarone is a multichannel blocking antiarrhythmic agent that has been shown to prevent atrial fibrillation/flutter (AF/AFl) recurrences in several multi-center trials. In the ANDROMEDA trial, dronedarone treatment increased mortality and cardiovascular hospitalizations patients with decompensated heart failure. In the ATHENA trial, dronedarone was used in elderly high risk patients with paroxysmal or persistent AF/AFl, excluding those with advanced heart failure, cardiovascular hospitalizations were significantly reduced. Dronedarone increased mortality and cardiovascular hospitalizations in a different patient group with permanent AF/AFl. Although organic toxicity from the drug is very rare, post-marketing data has reported rare hepatic toxicity associated with dronedarone use. Current guidelines position dronedarone as a front-line antiarrhythmic in many patients with AF/Fl. However, dronedarone should not be used in patients with advanced heart failure or in permanent AF. Clinical trial results have helped us define appropriate and inappropriate candidates for dronedarone.

Original languageEnglish (US)
Pages (from-to)467-475
Number of pages9
JournalCurrent Treatment Options in Cardiovascular Medicine
Volume15
Issue number4
DOIs
StatePublished - Aug 1 2013

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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