Aptamer-based nanofluidics for the molecular detection in ultra-small volume

Jinbin Yang, Hiroki Kamai, Yong Wang, Yan Xu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Molecular detection in samples with sub-picoliter (picoliter, pL =10−12 L) volumes is a challenge impeding the development of several fields such as single cell studies at the single molecule level. As a proof-of-concept study, here we proposed the aptamer-based nanofluidic device for the detection in samples with femtoliter (fL, 10−15 L) volumes. Platelet-derived growth factor BB (PDGF-BB) and its aptamers were used. The aptamers were modified onto the gold nanopattern surfaces inside nanochannels, and could recognize targets with high selectivity. This study proved that the aptamer-based nanofluidics is promising in bioanalysis area especially in the single-cell omics studies.

Original languageEnglish (US)
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages354-355
Number of pages2
ISBN (Electronic)9781733419017
StatePublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: Oct 4 2020Oct 9 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period10/4/2010/9/20

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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