Archaeal RNA polymerase

Akira Hirata, Katsuhiko S. Murakami

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

The recently solved X-ray crystal structures of archaeal RNA polymerase (RNAP) allow a structural comparison of the transcription machinery among all three domains of life. Archaeal transcription is very simple and all components, including the structures of general transcription factors and RNAP, are highly conserved in eukaryotes. Therefore, it could be a new model for the dissection of the eukaryotic transcription apparatus. The archaeal RNAP structure also provides a framework for addressing the functional role that Fe-S clusters play within the transcription machinery of archaea and eukaryotes. A comparison between bacterial and archaeal open complex models reveals likely key motifs of archaeal RNAP for DNA unwinding during the open complex formation.

Original languageEnglish (US)
Pages (from-to)724-731
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume19
Issue number6
DOIs
StatePublished - Dec 1 2009

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All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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