ArchAlign: Coordinate-free chromatin alignment reveals novel architectures

William K.M. Lai, Michael J. Buck

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Abstract

To facilitate identification and characterization of genomic functional elements, we have developed a chromatin architecture alignment algorithm (ArchAlign). ArchAlign identifies shared chromatin structural patterns from high-resolution chromatin structural datasets derived from next-generation sequencing or tiled microarray approaches for user defined regions of interest. We validated ArchAlign using well characterized functional elements, and used it to explore the chromatin structural architecture at CTCF binding sites in the human genome. ArchAlign is freely available at http://www.acsu.buffalo.edu/~mjbuck/ArchAlign.html.

Original languageEnglish (US)
Article numberR126
JournalGenome biology
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 23 2010

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All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

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