Arginine vasopressin and oxytocin modulate human social behavior

Richard P. Ebstein, Salomon Israel, Elad Lerer, Florina Uzefovsky, Idan Shalev, Inga Gritsenko, Mathias Riebold, Shahaf Salomon, Nurit Yirmiya

Research output: Chapter in Book/Report/Conference proceedingConference contribution

122 Citations (Scopus)

Abstract

Increasing evidence suggests that two nonapeptides, arginine vasopressin and oxytocin, shape human social behavior in both nonclinical and clinical subjects. Evidence is discussed that in autism spectrum disorders genetic polymorphisms in the vasopressin-oxytocin pathway, notably the arginine vasopressin receptor 1a (AVPR1a), the oxytocin receptor (OXTR), neurophysin I and II, and CD38 (recently shown to be critical for social behavior by mediating oxytocin secretion) contribute to deficits in socialization skills in this group of patients. We also present first evidence that CD38 expression in lymphoblastoid cells derived from subjects diagnosed with autism is correlated with social skill phenotype inventoried by the Vineland Adaptive Behavioral Scales. Additionally, we discuss molecular genetic evidence that in nonclinical subjects both AVPR1a and OXTR genes contribute to prosocial or altruistic behavior inventoried by two experimental paradigms, the dictator game and social values orientation. The role of the AVPR1a is also analyzed in prepulse inhibition. Prepulse inhibition of the startle response to auditory stimuli is a largely autonomic response that resonates with social cognition in both animal models and humans. First results are presented showing that intranasal administration of arginine vasopressin increases salivary cortisol levels in the Trier Social Stress test. To summarize, accumulating studies employing a broad array of cutting-edge tools in psychology, neuroeconomics, molecular genetics, pharmacology, electrophysiology, and brain imaging are beginning to elaborate the intriguing role of oxytocin and arginine vasopressin in human social behavior. We expect that future studies will continue this advance and deepen our understanding of these complex events.

Original languageEnglish (US)
Title of host publicationValues, Empathy, and Fairness across Social Barriers
PublisherBlackwell Publishing Inc.
Pages87-102
Number of pages16
ISBN (Print)9781573317603
DOIs
StatePublished - Jan 1 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1167
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Fingerprint

Vasotocin
Vasopressin Receptors
Arginine Vasopressin
Social Behavior
Oxytocin
Neurophysins
Oxytocin Receptors
Social Values
Molecular Biology
Startle Reflex
Electrophysiology
Intranasal Administration
Socialization
Genetic Polymorphisms
Autistic Disorder
Polymorphism
Vasopressins
Exercise Test
Neuroimaging
Cognition

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Ebstein, R. P., Israel, S., Lerer, E., Uzefovsky, F., Shalev, I., Gritsenko, I., ... Yirmiya, N. (2009). Arginine vasopressin and oxytocin modulate human social behavior. In Values, Empathy, and Fairness across Social Barriers (pp. 87-102). (Annals of the New York Academy of Sciences; Vol. 1167). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.04541.x
Ebstein, Richard P. ; Israel, Salomon ; Lerer, Elad ; Uzefovsky, Florina ; Shalev, Idan ; Gritsenko, Inga ; Riebold, Mathias ; Salomon, Shahaf ; Yirmiya, Nurit. / Arginine vasopressin and oxytocin modulate human social behavior. Values, Empathy, and Fairness across Social Barriers. Blackwell Publishing Inc., 2009. pp. 87-102 (Annals of the New York Academy of Sciences).
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Ebstein, RP, Israel, S, Lerer, E, Uzefovsky, F, Shalev, I, Gritsenko, I, Riebold, M, Salomon, S & Yirmiya, N 2009, Arginine vasopressin and oxytocin modulate human social behavior. in Values, Empathy, and Fairness across Social Barriers. Annals of the New York Academy of Sciences, vol. 1167, Blackwell Publishing Inc., pp. 87-102. https://doi.org/10.1111/j.1749-6632.2009.04541.x

Arginine vasopressin and oxytocin modulate human social behavior. / Ebstein, Richard P.; Israel, Salomon; Lerer, Elad; Uzefovsky, Florina; Shalev, Idan; Gritsenko, Inga; Riebold, Mathias; Salomon, Shahaf; Yirmiya, Nurit.

Values, Empathy, and Fairness across Social Barriers. Blackwell Publishing Inc., 2009. p. 87-102 (Annals of the New York Academy of Sciences; Vol. 1167).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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T1 - Arginine vasopressin and oxytocin modulate human social behavior

AU - Ebstein, Richard P.

AU - Israel, Salomon

AU - Lerer, Elad

AU - Uzefovsky, Florina

AU - Shalev, Idan

AU - Gritsenko, Inga

AU - Riebold, Mathias

AU - Salomon, Shahaf

AU - Yirmiya, Nurit

PY - 2009/1/1

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N2 - Increasing evidence suggests that two nonapeptides, arginine vasopressin and oxytocin, shape human social behavior in both nonclinical and clinical subjects. Evidence is discussed that in autism spectrum disorders genetic polymorphisms in the vasopressin-oxytocin pathway, notably the arginine vasopressin receptor 1a (AVPR1a), the oxytocin receptor (OXTR), neurophysin I and II, and CD38 (recently shown to be critical for social behavior by mediating oxytocin secretion) contribute to deficits in socialization skills in this group of patients. We also present first evidence that CD38 expression in lymphoblastoid cells derived from subjects diagnosed with autism is correlated with social skill phenotype inventoried by the Vineland Adaptive Behavioral Scales. Additionally, we discuss molecular genetic evidence that in nonclinical subjects both AVPR1a and OXTR genes contribute to prosocial or altruistic behavior inventoried by two experimental paradigms, the dictator game and social values orientation. The role of the AVPR1a is also analyzed in prepulse inhibition. Prepulse inhibition of the startle response to auditory stimuli is a largely autonomic response that resonates with social cognition in both animal models and humans. First results are presented showing that intranasal administration of arginine vasopressin increases salivary cortisol levels in the Trier Social Stress test. To summarize, accumulating studies employing a broad array of cutting-edge tools in psychology, neuroeconomics, molecular genetics, pharmacology, electrophysiology, and brain imaging are beginning to elaborate the intriguing role of oxytocin and arginine vasopressin in human social behavior. We expect that future studies will continue this advance and deepen our understanding of these complex events.

AB - Increasing evidence suggests that two nonapeptides, arginine vasopressin and oxytocin, shape human social behavior in both nonclinical and clinical subjects. Evidence is discussed that in autism spectrum disorders genetic polymorphisms in the vasopressin-oxytocin pathway, notably the arginine vasopressin receptor 1a (AVPR1a), the oxytocin receptor (OXTR), neurophysin I and II, and CD38 (recently shown to be critical for social behavior by mediating oxytocin secretion) contribute to deficits in socialization skills in this group of patients. We also present first evidence that CD38 expression in lymphoblastoid cells derived from subjects diagnosed with autism is correlated with social skill phenotype inventoried by the Vineland Adaptive Behavioral Scales. Additionally, we discuss molecular genetic evidence that in nonclinical subjects both AVPR1a and OXTR genes contribute to prosocial or altruistic behavior inventoried by two experimental paradigms, the dictator game and social values orientation. The role of the AVPR1a is also analyzed in prepulse inhibition. Prepulse inhibition of the startle response to auditory stimuli is a largely autonomic response that resonates with social cognition in both animal models and humans. First results are presented showing that intranasal administration of arginine vasopressin increases salivary cortisol levels in the Trier Social Stress test. To summarize, accumulating studies employing a broad array of cutting-edge tools in psychology, neuroeconomics, molecular genetics, pharmacology, electrophysiology, and brain imaging are beginning to elaborate the intriguing role of oxytocin and arginine vasopressin in human social behavior. We expect that future studies will continue this advance and deepen our understanding of these complex events.

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M3 - Conference contribution

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BT - Values, Empathy, and Fairness across Social Barriers

PB - Blackwell Publishing Inc.

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Ebstein RP, Israel S, Lerer E, Uzefovsky F, Shalev I, Gritsenko I et al. Arginine vasopressin and oxytocin modulate human social behavior. In Values, Empathy, and Fairness across Social Barriers. Blackwell Publishing Inc. 2009. p. 87-102. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2009.04541.x