Aromatase activity in primary and metastatic human breast cancer

Allan Lipton, Steven J. Santner, Richard J. Santen, Harold A. Harvey, Peter D. Feil, Deborah White‐Hershey, Mary J. Bartholomew, Charles E. Antle

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

Aromatase activity was measured in 104 primary and 24 metastatic breast cancer patients. The assay employed quantitates the production of 3H water release from 1β‐[3H] androstenedione after aromatization. Of 104 human primary breast tumors studied, 64 contained measurable aromatase activity, ranging from 5–70.5 pmol estrone formed/g protein/hour. In primary breast cancers there was no difference in levels of aromatase activity when analyzed by menstrual status or age by decade. Aromatase activity was similar in small and large primary tumors. The median aromatase activity of primary breast tumors (8.6 pmol/g/h) was similar to that found in metastatic breast cancer deposits (12.0 pmol/g/h). Aromatase activity did not correlate with either estrogen (ER) or progesterone (PR) receptor concentration in the tissues assayed. In this regard there were 33 ER PR tumor biopsies. Twelve of these 33 tumors contained aromatase activity greater than 10 pmol/g/hour. Cancer 59:779‐782, 1987.

Original languageEnglish (US)
Pages (from-to)779-782
Number of pages4
JournalCancer
Volume59
Issue number4
DOIs
StatePublished - Feb 15 1987

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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