Aromatase P450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty

Chanika Phornphutkul, Tomoharu Okubo, Kebin Wu, Zeev Harel, Thomas F. Tracy, Halit Pinar, Shiuan Chen, Philip A. Gruppuso, Gregory Goodwin

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

A 7-yr-old girl presented with isosexual precocious puberty secondary to a feminizing adrenal adenoma. The adrenal tumor was found to express aromatase messenger ribonucleic acid. Enzyme kinetic studies revealed a high level of aromatase activity in the adrenal tumor, with a Km of 45 nmol/L and a maximum velocity of 25.6 pmol/mg·h. Aromatase activity was approximately 500-fold higher in the tumor than in adjacent normal adrenal tissue. Although histopathological examination of the tumor was most consistent with a benign adenoma, the aromatase transcripts present in the tumor corresponded to those previously associated with malignant as well as benign tumors. We consider the pattern of aromatase expression sufficient to warrant continued follow-up for tumor recurrence. Our case demonstrates that isosexual precocious puberty secondary to a feminizing adrenal tumor can be due to estrogen synthesis from the tumor itself rather than peripheral aromatization as had been previously theorized.

Original languageEnglish (US)
Pages (from-to)649-652
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume86
Issue number2
DOIs
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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