Abstract
Many aspects of brain function are influenced by modulatory processes, including arousal. The most abrupt changes in arousal occur at the wake-sleep transition and at the induction of anesthetic conditions. They are accompanied by major electrophysiological changes, including an emergence of low-frequency (sleep-like) activity and a loss of mid-frequency (wake-like) activity that has been linked to feedback processes of the brain. Nevertheless, the causal relationship between these two types of electrophysiological changes, as well as the cortical mechanisms underlying changes in arousal and consciousness, remain poorly understood. To address this, we studied spontaneous electro-cortical activity during arousal changes in macaques. During sleep and at loss of consciousness induced by propofol anesthesia, we identified a prototypical sequence of cortical events in which the loss of mid-frequency activity preceded, by seconds, the increases in low-frequency activity. Furthermore, in visual areas, an influence of mid-frequency change onto high-frequency activity was observed across visual hierarchy. These results are consistent with the notion that drops in arousal and consciousness are facilitated by a release of feedback cortical inhibition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 222-231 |
| Number of pages | 10 |
| Journal | NeuroImage |
| Volume | 116 |
| DOIs | |
| State | Published - Aug 1 2015 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Cognitive Neuroscience
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Arousal transitions in sleep, wakefulness, and anesthesia are characterized by an orderly sequence of cortical events. / Liu, Xiao; Yanagawa, Toru; Leopold, David A.; Chang, Catie; Ishida, Hiroaki; Fujii, Naotaka; Duyn, Jeff H.
In: NeuroImage, Vol. 116, 01.08.2015, p. 222-231.Research output: Contribution to journal › Article
TY - JOUR
T1 - Arousal transitions in sleep, wakefulness, and anesthesia are characterized by an orderly sequence of cortical events
AU - Liu, Xiao
AU - Yanagawa, Toru
AU - Leopold, David A.
AU - Chang, Catie
AU - Ishida, Hiroaki
AU - Fujii, Naotaka
AU - Duyn, Jeff H.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Many aspects of brain function are influenced by modulatory processes, including arousal. The most abrupt changes in arousal occur at the wake-sleep transition and at the induction of anesthetic conditions. They are accompanied by major electrophysiological changes, including an emergence of low-frequency (sleep-like) activity and a loss of mid-frequency (wake-like) activity that has been linked to feedback processes of the brain. Nevertheless, the causal relationship between these two types of electrophysiological changes, as well as the cortical mechanisms underlying changes in arousal and consciousness, remain poorly understood. To address this, we studied spontaneous electro-cortical activity during arousal changes in macaques. During sleep and at loss of consciousness induced by propofol anesthesia, we identified a prototypical sequence of cortical events in which the loss of mid-frequency activity preceded, by seconds, the increases in low-frequency activity. Furthermore, in visual areas, an influence of mid-frequency change onto high-frequency activity was observed across visual hierarchy. These results are consistent with the notion that drops in arousal and consciousness are facilitated by a release of feedback cortical inhibition.
AB - Many aspects of brain function are influenced by modulatory processes, including arousal. The most abrupt changes in arousal occur at the wake-sleep transition and at the induction of anesthetic conditions. They are accompanied by major electrophysiological changes, including an emergence of low-frequency (sleep-like) activity and a loss of mid-frequency (wake-like) activity that has been linked to feedback processes of the brain. Nevertheless, the causal relationship between these two types of electrophysiological changes, as well as the cortical mechanisms underlying changes in arousal and consciousness, remain poorly understood. To address this, we studied spontaneous electro-cortical activity during arousal changes in macaques. During sleep and at loss of consciousness induced by propofol anesthesia, we identified a prototypical sequence of cortical events in which the loss of mid-frequency activity preceded, by seconds, the increases in low-frequency activity. Furthermore, in visual areas, an influence of mid-frequency change onto high-frequency activity was observed across visual hierarchy. These results are consistent with the notion that drops in arousal and consciousness are facilitated by a release of feedback cortical inhibition.
UR - http://www.scopus.com/inward/record.url?scp=84954197529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954197529&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2015.04.003
DO - 10.1016/j.neuroimage.2015.04.003
M3 - Article
C2 - 25865143
AN - SCOPUS:84954197529
VL - 116
SP - 222
EP - 231
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
ER -