Arousal transitions in sleep, wakefulness, and anesthesia are characterized by an orderly sequence of cortical events

Xiao Liu, Toru Yanagawa, David A. Leopold, Catie Chang, Hiroaki Ishida, Naotaka Fujii, Jeff H. Duyn

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Many aspects of brain function are influenced by modulatory processes, including arousal. The most abrupt changes in arousal occur at the wake-sleep transition and at the induction of anesthetic conditions. They are accompanied by major electrophysiological changes, including an emergence of low-frequency (sleep-like) activity and a loss of mid-frequency (wake-like) activity that has been linked to feedback processes of the brain. Nevertheless, the causal relationship between these two types of electrophysiological changes, as well as the cortical mechanisms underlying changes in arousal and consciousness, remain poorly understood. To address this, we studied spontaneous electro-cortical activity during arousal changes in macaques. During sleep and at loss of consciousness induced by propofol anesthesia, we identified a prototypical sequence of cortical events in which the loss of mid-frequency activity preceded, by seconds, the increases in low-frequency activity. Furthermore, in visual areas, an influence of mid-frequency change onto high-frequency activity was observed across visual hierarchy. These results are consistent with the notion that drops in arousal and consciousness are facilitated by a release of feedback cortical inhibition.

Original languageEnglish (US)
Pages (from-to)222-231
Number of pages10
JournalNeuroImage
Volume116
DOIs
StatePublished - Aug 1 2015

Fingerprint

Wakefulness
Arousal
Sleep
Anesthesia
Consciousness
Unconsciousness
Brain
Macaca
Propofol
Anesthetics

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Liu, Xiao ; Yanagawa, Toru ; Leopold, David A. ; Chang, Catie ; Ishida, Hiroaki ; Fujii, Naotaka ; Duyn, Jeff H. / Arousal transitions in sleep, wakefulness, and anesthesia are characterized by an orderly sequence of cortical events. In: NeuroImage. 2015 ; Vol. 116. pp. 222-231.
@article{9dc4962fce2c43289504cbd926a9576b,
title = "Arousal transitions in sleep, wakefulness, and anesthesia are characterized by an orderly sequence of cortical events",
abstract = "Many aspects of brain function are influenced by modulatory processes, including arousal. The most abrupt changes in arousal occur at the wake-sleep transition and at the induction of anesthetic conditions. They are accompanied by major electrophysiological changes, including an emergence of low-frequency (sleep-like) activity and a loss of mid-frequency (wake-like) activity that has been linked to feedback processes of the brain. Nevertheless, the causal relationship between these two types of electrophysiological changes, as well as the cortical mechanisms underlying changes in arousal and consciousness, remain poorly understood. To address this, we studied spontaneous electro-cortical activity during arousal changes in macaques. During sleep and at loss of consciousness induced by propofol anesthesia, we identified a prototypical sequence of cortical events in which the loss of mid-frequency activity preceded, by seconds, the increases in low-frequency activity. Furthermore, in visual areas, an influence of mid-frequency change onto high-frequency activity was observed across visual hierarchy. These results are consistent with the notion that drops in arousal and consciousness are facilitated by a release of feedback cortical inhibition.",
author = "Xiao Liu and Toru Yanagawa and Leopold, {David A.} and Catie Chang and Hiroaki Ishida and Naotaka Fujii and Duyn, {Jeff H.}",
year = "2015",
month = "8",
day = "1",
doi = "10.1016/j.neuroimage.2015.04.003",
language = "English (US)",
volume = "116",
pages = "222--231",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

Arousal transitions in sleep, wakefulness, and anesthesia are characterized by an orderly sequence of cortical events. / Liu, Xiao; Yanagawa, Toru; Leopold, David A.; Chang, Catie; Ishida, Hiroaki; Fujii, Naotaka; Duyn, Jeff H.

In: NeuroImage, Vol. 116, 01.08.2015, p. 222-231.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Arousal transitions in sleep, wakefulness, and anesthesia are characterized by an orderly sequence of cortical events

AU - Liu, Xiao

AU - Yanagawa, Toru

AU - Leopold, David A.

AU - Chang, Catie

AU - Ishida, Hiroaki

AU - Fujii, Naotaka

AU - Duyn, Jeff H.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Many aspects of brain function are influenced by modulatory processes, including arousal. The most abrupt changes in arousal occur at the wake-sleep transition and at the induction of anesthetic conditions. They are accompanied by major electrophysiological changes, including an emergence of low-frequency (sleep-like) activity and a loss of mid-frequency (wake-like) activity that has been linked to feedback processes of the brain. Nevertheless, the causal relationship between these two types of electrophysiological changes, as well as the cortical mechanisms underlying changes in arousal and consciousness, remain poorly understood. To address this, we studied spontaneous electro-cortical activity during arousal changes in macaques. During sleep and at loss of consciousness induced by propofol anesthesia, we identified a prototypical sequence of cortical events in which the loss of mid-frequency activity preceded, by seconds, the increases in low-frequency activity. Furthermore, in visual areas, an influence of mid-frequency change onto high-frequency activity was observed across visual hierarchy. These results are consistent with the notion that drops in arousal and consciousness are facilitated by a release of feedback cortical inhibition.

AB - Many aspects of brain function are influenced by modulatory processes, including arousal. The most abrupt changes in arousal occur at the wake-sleep transition and at the induction of anesthetic conditions. They are accompanied by major electrophysiological changes, including an emergence of low-frequency (sleep-like) activity and a loss of mid-frequency (wake-like) activity that has been linked to feedback processes of the brain. Nevertheless, the causal relationship between these two types of electrophysiological changes, as well as the cortical mechanisms underlying changes in arousal and consciousness, remain poorly understood. To address this, we studied spontaneous electro-cortical activity during arousal changes in macaques. During sleep and at loss of consciousness induced by propofol anesthesia, we identified a prototypical sequence of cortical events in which the loss of mid-frequency activity preceded, by seconds, the increases in low-frequency activity. Furthermore, in visual areas, an influence of mid-frequency change onto high-frequency activity was observed across visual hierarchy. These results are consistent with the notion that drops in arousal and consciousness are facilitated by a release of feedback cortical inhibition.

UR - http://www.scopus.com/inward/record.url?scp=84954197529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954197529&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2015.04.003

DO - 10.1016/j.neuroimage.2015.04.003

M3 - Article

C2 - 25865143

AN - SCOPUS:84954197529

VL - 116

SP - 222

EP - 231

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -