Arsenic exposure and cognitive performance in Mexican Schoolchildren

Jorge L. Rosado, Dolores Ronquillo, Katarzyna Kordas, Olga Rojas, Javier Alatorre, Patricia Lopez, Gonzalo Garcia-Vargas, María del Carmen Caamaño, Mariano E. Cebrián, Rebecca J. Stoltzfus

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Background: Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans. Objective: Our goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age children. Methods: We recruited 602 children 6-8 years of age living within 3.5 km of a metallurgic smelter complex in the city of Torreón, Mexico, to participate in a cross-sectional evaluation. Of these, 591 had complete anthropometry, iron, and zinc status by biochemical measurements in serum, blood lead concentration (PbB), and arsenic in urine (UAs), and 557 completed several cognitive performance tests. Results: The mean for UAs was 58.1 ± 33.2 μg/L; 52% of the children had UAs concentrations > 50 μg/L, and 50.7% of children had PbB ≥ 10 μg/dL. UAs concentration was associated with low socioeconomic status. Nutritional status indicators were not related to UAs concentrations. Linear and logistic regressions adjusted for hemoglobin concentration, PbB, and sociodemographic confounders showed a significant inverse association between UAs and Visual-Spatial Abilities with Figure Design, the Peabody Picture Vocabulary Test, the WISC-RM Digit Span subscale, Visual Search, and Letter Sequencing Tests (p < 0.05). Boys excreted significantly more UAs (p < 0.05) and were affected on different cognitive areas than girls. Conclusions: Children living in an area contaminated with both As and lead showed that As contamination can affect children's cognitive development, independent of any effect of lead.

Original languageEnglish (US)
Pages (from-to)1371-1375
Number of pages5
JournalEnvironmental health perspectives
Volume115
Issue number9
DOIs
StatePublished - Sep 1 2007

Fingerprint

Arsenic
Cognition
Language Tests
Anthropometry
Child Development
Mexico
Nutritional Status
Social Class
Zinc
Linear Models
Hemoglobins
Iron
Logistic Models
Demography
Urine
Serum
Lead

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Rosado, J. L., Ronquillo, D., Kordas, K., Rojas, O., Alatorre, J., Lopez, P., ... Stoltzfus, R. J. (2007). Arsenic exposure and cognitive performance in Mexican Schoolchildren. Environmental health perspectives, 115(9), 1371-1375. https://doi.org/10.1289/ehp.9961
Rosado, Jorge L. ; Ronquillo, Dolores ; Kordas, Katarzyna ; Rojas, Olga ; Alatorre, Javier ; Lopez, Patricia ; Garcia-Vargas, Gonzalo ; del Carmen Caamaño, María ; Cebrián, Mariano E. ; Stoltzfus, Rebecca J. / Arsenic exposure and cognitive performance in Mexican Schoolchildren. In: Environmental health perspectives. 2007 ; Vol. 115, No. 9. pp. 1371-1375.
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Rosado, JL, Ronquillo, D, Kordas, K, Rojas, O, Alatorre, J, Lopez, P, Garcia-Vargas, G, del Carmen Caamaño, M, Cebrián, ME & Stoltzfus, RJ 2007, 'Arsenic exposure and cognitive performance in Mexican Schoolchildren', Environmental health perspectives, vol. 115, no. 9, pp. 1371-1375. https://doi.org/10.1289/ehp.9961

Arsenic exposure and cognitive performance in Mexican Schoolchildren. / Rosado, Jorge L.; Ronquillo, Dolores; Kordas, Katarzyna; Rojas, Olga; Alatorre, Javier; Lopez, Patricia; Garcia-Vargas, Gonzalo; del Carmen Caamaño, María; Cebrián, Mariano E.; Stoltzfus, Rebecca J.

In: Environmental health perspectives, Vol. 115, No. 9, 01.09.2007, p. 1371-1375.

Research output: Contribution to journalArticle

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T1 - Arsenic exposure and cognitive performance in Mexican Schoolchildren

AU - Rosado, Jorge L.

AU - Ronquillo, Dolores

AU - Kordas, Katarzyna

AU - Rojas, Olga

AU - Alatorre, Javier

AU - Lopez, Patricia

AU - Garcia-Vargas, Gonzalo

AU - del Carmen Caamaño, María

AU - Cebrián, Mariano E.

AU - Stoltzfus, Rebecca J.

PY - 2007/9/1

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N2 - Background: Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans. Objective: Our goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age children. Methods: We recruited 602 children 6-8 years of age living within 3.5 km of a metallurgic smelter complex in the city of Torreón, Mexico, to participate in a cross-sectional evaluation. Of these, 591 had complete anthropometry, iron, and zinc status by biochemical measurements in serum, blood lead concentration (PbB), and arsenic in urine (UAs), and 557 completed several cognitive performance tests. Results: The mean for UAs was 58.1 ± 33.2 μg/L; 52% of the children had UAs concentrations > 50 μg/L, and 50.7% of children had PbB ≥ 10 μg/dL. UAs concentration was associated with low socioeconomic status. Nutritional status indicators were not related to UAs concentrations. Linear and logistic regressions adjusted for hemoglobin concentration, PbB, and sociodemographic confounders showed a significant inverse association between UAs and Visual-Spatial Abilities with Figure Design, the Peabody Picture Vocabulary Test, the WISC-RM Digit Span subscale, Visual Search, and Letter Sequencing Tests (p < 0.05). Boys excreted significantly more UAs (p < 0.05) and were affected on different cognitive areas than girls. Conclusions: Children living in an area contaminated with both As and lead showed that As contamination can affect children's cognitive development, independent of any effect of lead.

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Rosado JL, Ronquillo D, Kordas K, Rojas O, Alatorre J, Lopez P et al. Arsenic exposure and cognitive performance in Mexican Schoolchildren. Environmental health perspectives. 2007 Sep 1;115(9):1371-1375. https://doi.org/10.1289/ehp.9961