Arterial baroreceptors mediate the inhibitory effect of acute increases in arterial blood pressure on thirst

Sean D. Stocker, Edward M. Stricker, Alan F. Sved

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The present study sought to determine whether arterial baroreceptor afferents mediate the inhibitory effect of an acute increase in arterial blood pressure (AP) on thirst stimulated by systemically administered ANG II or by hyperosmolality. Approximately 2 wk after sinoaortic denervation, one of four doses of ANG II (10, 40, 100, or 250 ng·kg-1·min-1) was infused intravenously in control and complete sinoaortic-denervated (SAD) rats. Complete SAD rats ingested more water than control rats when infused with 40, 100, or 250 ng·kg-1·min-1 ANG II. Furthermore, complete SAD rats displayed significantly shorter latencies to drink compared with control rats. In a separate group of rats, drinking behavior was stimulated by increases in plasma osmolality, and mean AP was raised by an infusion of phenylephrine (PE). The infusion of PE significantly reduced water intake and lengthened the latencies to drink in control rats but not in complete SAD rats. In all experiments, drinking behavior of rats that were subjected to sinoaortic denervation surgery but had residual baroreceptor reflex function (partial SAD rats) was similar to that of control rats. Thus it appears that arterial baroreceptor afferents mediate the inhibitory effect of an acute increase in AP on thirst stimulated by ANG II or hyperosmolality.

Original languageEnglish (US)
Pages (from-to)R1718-R1729
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume282
Issue number6 51-6
StatePublished - Jul 2 2002

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Thirst
Pressoreceptors
Arterial Pressure
Drinking Behavior
Phenylephrine
Denervation
Baroreflex
Osmolar Concentration
Drinking

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

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Arterial baroreceptors mediate the inhibitory effect of acute increases in arterial blood pressure on thirst. / Stocker, Sean D.; Stricker, Edward M.; Sved, Alan F.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 282, No. 6 51-6, 02.07.2002, p. R1718-R1729.

Research output: Contribution to journalArticle

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