Evidence is accumulating in support of the plausible notion that lower arterial elasticity is associated with an increased risk of cardiovascular disease manifestations. Conventional indices of arterial stiffness are compared to a newer method (blood pressure-adjusted pulsatile arterial diameter change) in terms of blood pressure dependence. Impaired elasticity of larger arteries is an antecedent factor in the natural history of blood pressure elevation at the population level. Strong evidence supports the notion that lower arterial elasticity in the medium-sized arteries is associated with the development of hypertension.
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