Arterial stiffness and the development of hypertension

The ARIC study

Duanping Liao, Donna K. Arnett, Herman A. Tyroler, Ward A. Riley, Lloyd E. Chambless, Moyses Szklo, Gerardo Heiss

Research output: Contribution to journalArticle

362 Citations (Scopus)

Abstract

Decreased elasticity in large and medium-sized arteries has been postulated to be associated with cardiovascular diseases. We prospectively examined the relation between arterial elasticity and the development of hypertension over 6 years of follow-up in a cohort of 6992 normotensive men and women aged 45 to 64 years at baseline from the biracial, population-based Atherosclerosis Risk in Communities (ARIC) Study. Arterial elasticity was measured from high-resolution B-mode ultrasound examination of the left common carotid artery as adjusted arterial diameter change (in micrometers, simultaneously adjusted for diastolic blood pressure, pulse pressure, pulse pressure squared, diastolic arterial diameter, and height), Peterson's elastic modulus (in kilopascals), Young's elastic modulus (in kilopascals), and β stiffness index. Incident hypertension (n=551) was defined as systolic blood pressure ≥160 mm Hg, diastolic blood pressure ≥95 mm Hg, or the use of antihypertensive medication at a follow-up examination conducted every 3 years. The age-, ethnicity-, center-, gender-, education-, smoking-, heart rate-, and obesity-adjusted means (SE) of baseline adjusted arterial diameter change, Peterson's elastic modulus, Young's elastic modulus, and β stiffness index were 397 (5), 148 (2.0), 787 (12.7), and 11.43 (0.16), respectively, in persons who developed hypertension during follow-up, in contrast to 407 (1), 124 (0.6), 681 (3.7), and 10.34 (0.05), respectively, for persons who did not. The similarly adjusted cumulative incident rates of hypertension from the highest to the lowest quartiles of arterial elasticity were 6.7%, 8.0%, 7.3%, and 9.6%, respectively, when measured by adjusted arterial diameter change (P<0.01). One standard deviation decrease in arterial elasticity was associated with 15% greater risk of hypertension, independent of established risk factors for hypertension and the level of baseline blood pressure. These results suggest that lower arterial elasticity is related to the development of hypertension.

Original languageEnglish (US)
Pages (from-to)201-206
Number of pages6
JournalHypertension
Volume34
Issue number2
DOIs
StatePublished - Jan 1 1999

Fingerprint

Vascular Stiffness
Atherosclerosis
Elastic Modulus
Elasticity
Blood Pressure
Hypertension
Common Carotid Artery
Antihypertensive Agents
Cardiovascular Diseases
Arteries
Obesity
Heart Rate
Smoking
Education

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Liao, D., Arnett, D. K., Tyroler, H. A., Riley, W. A., Chambless, L. E., Szklo, M., & Heiss, G. (1999). Arterial stiffness and the development of hypertension: The ARIC study. Hypertension, 34(2), 201-206. https://doi.org/10.1161/01.HYP.34.2.201
Liao, Duanping ; Arnett, Donna K. ; Tyroler, Herman A. ; Riley, Ward A. ; Chambless, Lloyd E. ; Szklo, Moyses ; Heiss, Gerardo. / Arterial stiffness and the development of hypertension : The ARIC study. In: Hypertension. 1999 ; Vol. 34, No. 2. pp. 201-206.
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Liao, D, Arnett, DK, Tyroler, HA, Riley, WA, Chambless, LE, Szklo, M & Heiss, G 1999, 'Arterial stiffness and the development of hypertension: The ARIC study', Hypertension, vol. 34, no. 2, pp. 201-206. https://doi.org/10.1161/01.HYP.34.2.201

Arterial stiffness and the development of hypertension : The ARIC study. / Liao, Duanping; Arnett, Donna K.; Tyroler, Herman A.; Riley, Ward A.; Chambless, Lloyd E.; Szklo, Moyses; Heiss, Gerardo.

In: Hypertension, Vol. 34, No. 2, 01.01.1999, p. 201-206.

Research output: Contribution to journalArticle

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Liao D, Arnett DK, Tyroler HA, Riley WA, Chambless LE, Szklo M et al. Arterial stiffness and the development of hypertension: The ARIC study. Hypertension. 1999 Jan 1;34(2):201-206. https://doi.org/10.1161/01.HYP.34.2.201