Ascorbic acid and the behavioral response to haloperidol: Implications for the action of antipsychotic drugs

George V. Rebec, Josephine M. Centore, Laura K. White, Kevin D. Alloway

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Haloperidol, a widely used antipsychotic drug, was tested for its ability to block the behavioral response to amphetamine and to elicit catalepsy in rats treated with saline or ascorbic acid (1000 milligrams per kilogram of body weight). By itself, ascorbic acid failed to exert significant behavioral effects, but it enhanced the antiamphetamine and cataleptogenic effects of haloperidol (0.1 or 0.5 milligrams per kilogram). These results, combined with a growing body of biochemical evidence, suggest that ascorbic acid plays an important role in modulating the behavioral effects of haloperidol and related antipsychotic drugs.

Original languageEnglish (US)
Pages (from-to)438-440
Number of pages3
JournalScience
Volume227
Issue number4685
DOIs
StatePublished - Jan 1 1985

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Haloperidol
Antipsychotic Agents
Ascorbic Acid
Catalepsy
Amphetamine
Body Weight

All Science Journal Classification (ASJC) codes

  • General

Cite this

Rebec, George V. ; Centore, Josephine M. ; White, Laura K. ; Alloway, Kevin D. / Ascorbic acid and the behavioral response to haloperidol : Implications for the action of antipsychotic drugs. In: Science. 1985 ; Vol. 227, No. 4685. pp. 438-440.
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Ascorbic acid and the behavioral response to haloperidol : Implications for the action of antipsychotic drugs. / Rebec, George V.; Centore, Josephine M.; White, Laura K.; Alloway, Kevin D.

In: Science, Vol. 227, No. 4685, 01.01.1985, p. 438-440.

Research output: Contribution to journalArticle

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