Ascorbic acid does not enhance Hypoxia-Induced Vasodilation in healthy older men

Jonathan P. Pollock, Hardikkumar M. Patel, Brittney J. Randolph, Matthew J. Heffernan, Urs Leuenberger, Matthew Muller

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In response to hypoxia, a net vasodilation occurs in the limb vasculature in young healthy humans and this is referred to as “hypoxia-induced vasodilation”. We performed two separate experiments to determine (1) if hypoxiainduced forearm vasodilation is impaired in older men (n = 8) compared to young men (n = 7) and (2) if acute systemic infusion of ascorbic acid would enhance hypoxia-induced vasodilation in older men (n = 8). Heart rate, mean arterial pressure, oxygen saturation, minute ventilation, forearm vascular conductance (FVC, Doppler ultrasound), and cutaneous vascular conductance (CVC, laser Doppler flowmetry) were recorded continuously while subjects breathed 10% oxygen for 5 min. Changes from baseline were compared between groups and between treatments. The older adults had a significantly attenuated increase in FBF (13 ± 4 vs. 30 ± 7%) and FVC (16 ± 4 vs. 30 ± 7%) in response to 5 min of hypoxia. However, skin blood flow responses were comparable between groups (young: 35 ± 9, older: 30 ± 6%). In Experiment 2, FVC responses to 5 min of breathing 10% oxygen were not significantly different following saline (3 ± 10%) and ascorbic acid (8 ± 10%) in the older men. Ascorbic acid also had no physiological effects in the young men. These findings advance our basic understanding of how aging influences vascular responses to hypoxia and suggest that, in healthy humans, hypoxiainduced vasodilation is not restrained by reactive oxygen species.

Original languageEnglish (US)
Article numbere12091
JournalPhysiological reports
Volume2
Issue number7
DOIs
StatePublished - Jan 1 2014

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Vasodilation
Ascorbic Acid
Blood Vessels
Oxygen
Forearm
Doppler Ultrasonography
Skin
Laser-Doppler Flowmetry
Ventilation
Reactive Oxygen Species
Arterial Pressure
Respiration
Extremities
Heart Rate
Hypoxia
Therapeutics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Pollock, J. P., Patel, H. M., Randolph, B. J., Heffernan, M. J., Leuenberger, U., & Muller, M. (2014). Ascorbic acid does not enhance Hypoxia-Induced Vasodilation in healthy older men. Physiological reports, 2(7), [e12091]. https://doi.org/10.14814/phy2.12091
Pollock, Jonathan P. ; Patel, Hardikkumar M. ; Randolph, Brittney J. ; Heffernan, Matthew J. ; Leuenberger, Urs ; Muller, Matthew. / Ascorbic acid does not enhance Hypoxia-Induced Vasodilation in healthy older men. In: Physiological reports. 2014 ; Vol. 2, No. 7.
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Ascorbic acid does not enhance Hypoxia-Induced Vasodilation in healthy older men. / Pollock, Jonathan P.; Patel, Hardikkumar M.; Randolph, Brittney J.; Heffernan, Matthew J.; Leuenberger, Urs; Muller, Matthew.

In: Physiological reports, Vol. 2, No. 7, e12091, 01.01.2014.

Research output: Contribution to journalArticle

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