Aspergillosis of the cranial base

M. M. Carr, M. D. Cusimano, P. J. Muller, J. Bilbao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aspergillus is an ubiquitous organism seldom pathogenic in normal hosts. Aspergillus osteomyelitis of the spine occurs rarely in immunocompromised patients as a result of hematogenous spread from distant foci. We present a case of Aspergillus osteomyelitis in the region of the jugular foramen in a previously healthy male with no antecedent event. He presented with dysphagia, hypophonia, and weight loss of several months duration. Diagnosis was delayed due to nonspecific results of various imaging tests. We review the clinical course of fungal osteomyelitis, including appearance on magnetic resonance imaging and computed tomography, culture characteristics, and gross appearance. Current treatment consists of surgical debridement and antifungal medications such as amphotericin B and itraconazole, and the efficacy of these are discussed.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalSkull Base Surgery
Volume4
Issue number3
DOIs
StatePublished - Jan 1 1994

Fingerprint

Aspergillosis
Skull Base
Osteomyelitis
Aspergillus
Itraconazole
Delayed Diagnosis
Immunocompromised Host
Amphotericin B
Debridement
Deglutition Disorders
Weight Loss
Spine
Neck
Tomography
Magnetic Resonance Imaging
Therapeutics

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Carr, M. M., Cusimano, M. D., Muller, P. J., & Bilbao, J. (1994). Aspergillosis of the cranial base. Skull Base Surgery, 4(3), 159-163. https://doi.org/10.1055/s-2008-1058968
Carr, M. M. ; Cusimano, M. D. ; Muller, P. J. ; Bilbao, J. / Aspergillosis of the cranial base. In: Skull Base Surgery. 1994 ; Vol. 4, No. 3. pp. 159-163.
@article{30221ef81f90495eac830593cd6b10cd,
title = "Aspergillosis of the cranial base",
abstract = "Aspergillus is an ubiquitous organism seldom pathogenic in normal hosts. Aspergillus osteomyelitis of the spine occurs rarely in immunocompromised patients as a result of hematogenous spread from distant foci. We present a case of Aspergillus osteomyelitis in the region of the jugular foramen in a previously healthy male with no antecedent event. He presented with dysphagia, hypophonia, and weight loss of several months duration. Diagnosis was delayed due to nonspecific results of various imaging tests. We review the clinical course of fungal osteomyelitis, including appearance on magnetic resonance imaging and computed tomography, culture characteristics, and gross appearance. Current treatment consists of surgical debridement and antifungal medications such as amphotericin B and itraconazole, and the efficacy of these are discussed.",
author = "Carr, {M. M.} and Cusimano, {M. D.} and Muller, {P. J.} and J. Bilbao",
year = "1994",
month = "1",
day = "1",
doi = "10.1055/s-2008-1058968",
language = "English (US)",
volume = "4",
pages = "159--163",
journal = "Journal of Neurological Surgery, Part B: Skull Base",
issn = "2193-6331",
publisher = "Thieme Medical Publishers",
number = "3",

}

Carr, MM, Cusimano, MD, Muller, PJ & Bilbao, J 1994, 'Aspergillosis of the cranial base', Skull Base Surgery, vol. 4, no. 3, pp. 159-163. https://doi.org/10.1055/s-2008-1058968

Aspergillosis of the cranial base. / Carr, M. M.; Cusimano, M. D.; Muller, P. J.; Bilbao, J.

In: Skull Base Surgery, Vol. 4, No. 3, 01.01.1994, p. 159-163.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Aspergillosis of the cranial base

AU - Carr, M. M.

AU - Cusimano, M. D.

AU - Muller, P. J.

AU - Bilbao, J.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Aspergillus is an ubiquitous organism seldom pathogenic in normal hosts. Aspergillus osteomyelitis of the spine occurs rarely in immunocompromised patients as a result of hematogenous spread from distant foci. We present a case of Aspergillus osteomyelitis in the region of the jugular foramen in a previously healthy male with no antecedent event. He presented with dysphagia, hypophonia, and weight loss of several months duration. Diagnosis was delayed due to nonspecific results of various imaging tests. We review the clinical course of fungal osteomyelitis, including appearance on magnetic resonance imaging and computed tomography, culture characteristics, and gross appearance. Current treatment consists of surgical debridement and antifungal medications such as amphotericin B and itraconazole, and the efficacy of these are discussed.

AB - Aspergillus is an ubiquitous organism seldom pathogenic in normal hosts. Aspergillus osteomyelitis of the spine occurs rarely in immunocompromised patients as a result of hematogenous spread from distant foci. We present a case of Aspergillus osteomyelitis in the region of the jugular foramen in a previously healthy male with no antecedent event. He presented with dysphagia, hypophonia, and weight loss of several months duration. Diagnosis was delayed due to nonspecific results of various imaging tests. We review the clinical course of fungal osteomyelitis, including appearance on magnetic resonance imaging and computed tomography, culture characteristics, and gross appearance. Current treatment consists of surgical debridement and antifungal medications such as amphotericin B and itraconazole, and the efficacy of these are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0028111104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028111104&partnerID=8YFLogxK

U2 - 10.1055/s-2008-1058968

DO - 10.1055/s-2008-1058968

M3 - Article

C2 - 17171166

AN - SCOPUS:0028111104

VL - 4

SP - 159

EP - 163

JO - Journal of Neurological Surgery, Part B: Skull Base

JF - Journal of Neurological Surgery, Part B: Skull Base

SN - 2193-6331

IS - 3

ER -

Carr MM, Cusimano MD, Muller PJ, Bilbao J. Aspergillosis of the cranial base. Skull Base Surgery. 1994 Jan 1;4(3):159-163. https://doi.org/10.1055/s-2008-1058968