Assessing the epidemiological effect of wolbachia for dengue control

Louis Lambrechts, Neil M. Ferguson, Eva Harris, Edward C. Holmes, Elizabeth A. McGraw, Scott L. O'Neill, Eng E. Ooi, Scott A. Ritchie, Peter A. Ryan, Thomas W. Scott, Cameron P. Simmons, Scott C. Weaver

Research output: Contribution to journalComment/debate

34 Citations (Scopus)

Abstract

Dengue viruses cause more human morbidity and mortality than any other arthropod-borne virus. Dengue prevention relies mainly on vector control; however, the failure of traditional methods has promoted the development of novel entomological approaches. Although use of the intracellular bacterium wolbachia to control mosquito populations was proposed 50 years ago, only in the past decade has its use as a potential agent of dengue control gained substantial interest. Here, we review evidence that supports a practical approach for dengue reduction through field release of wolbachia-infected mosquitoes and discuss the additional studies that have to be done before the strategy can be validated and implemented. A crucial next step is to assess the efficacy of wolbachia in reducing dengue virus transmission. We argue that a cluster randomised trial is at this time premature because choice of wolbachia strain for release and deployment strategies are still being optimised. We therefore present a pragmatic approach to acquiring preliminary evidence of efficacy through various complementary methods including a prospective cohort study, a geographical cluster investigation, virus phylogenetic analysis, virus surveillance in mosquitoes, and vector competence assays. This multipronged approach could provide valuable intermediate evidence of efficacy to justify a future cluster randomised trial.

Original languageEnglish (US)
Pages (from-to)862-866
Number of pages5
JournalThe Lancet Infectious Diseases
Volume15
Issue number7
DOIs
StatePublished - Jul 1 2015

Fingerprint

Wolbachia
Dengue
Dengue Virus
Mosquito Control
Viruses
Arboviruses
Culicidae
Mental Competency
Cohort Studies
Prospective Studies
Morbidity
Bacteria
Mortality
Population

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

Cite this

Lambrechts, L., Ferguson, N. M., Harris, E., Holmes, E. C., McGraw, E. A., O'Neill, S. L., ... Weaver, S. C. (2015). Assessing the epidemiological effect of wolbachia for dengue control. The Lancet Infectious Diseases, 15(7), 862-866. https://doi.org/10.1016/S1473-3099(15)00091-2
Lambrechts, Louis ; Ferguson, Neil M. ; Harris, Eva ; Holmes, Edward C. ; McGraw, Elizabeth A. ; O'Neill, Scott L. ; Ooi, Eng E. ; Ritchie, Scott A. ; Ryan, Peter A. ; Scott, Thomas W. ; Simmons, Cameron P. ; Weaver, Scott C. / Assessing the epidemiological effect of wolbachia for dengue control. In: The Lancet Infectious Diseases. 2015 ; Vol. 15, No. 7. pp. 862-866.
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Lambrechts, L, Ferguson, NM, Harris, E, Holmes, EC, McGraw, EA, O'Neill, SL, Ooi, EE, Ritchie, SA, Ryan, PA, Scott, TW, Simmons, CP & Weaver, SC 2015, 'Assessing the epidemiological effect of wolbachia for dengue control', The Lancet Infectious Diseases, vol. 15, no. 7, pp. 862-866. https://doi.org/10.1016/S1473-3099(15)00091-2

Assessing the epidemiological effect of wolbachia for dengue control. / Lambrechts, Louis; Ferguson, Neil M.; Harris, Eva; Holmes, Edward C.; McGraw, Elizabeth A.; O'Neill, Scott L.; Ooi, Eng E.; Ritchie, Scott A.; Ryan, Peter A.; Scott, Thomas W.; Simmons, Cameron P.; Weaver, Scott C.

In: The Lancet Infectious Diseases, Vol. 15, No. 7, 01.07.2015, p. 862-866.

Research output: Contribution to journalComment/debate

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T1 - Assessing the epidemiological effect of wolbachia for dengue control

AU - Lambrechts, Louis

AU - Ferguson, Neil M.

AU - Harris, Eva

AU - Holmes, Edward C.

AU - McGraw, Elizabeth A.

AU - O'Neill, Scott L.

AU - Ooi, Eng E.

AU - Ritchie, Scott A.

AU - Ryan, Peter A.

AU - Scott, Thomas W.

AU - Simmons, Cameron P.

AU - Weaver, Scott C.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Dengue viruses cause more human morbidity and mortality than any other arthropod-borne virus. Dengue prevention relies mainly on vector control; however, the failure of traditional methods has promoted the development of novel entomological approaches. Although use of the intracellular bacterium wolbachia to control mosquito populations was proposed 50 years ago, only in the past decade has its use as a potential agent of dengue control gained substantial interest. Here, we review evidence that supports a practical approach for dengue reduction through field release of wolbachia-infected mosquitoes and discuss the additional studies that have to be done before the strategy can be validated and implemented. A crucial next step is to assess the efficacy of wolbachia in reducing dengue virus transmission. We argue that a cluster randomised trial is at this time premature because choice of wolbachia strain for release and deployment strategies are still being optimised. We therefore present a pragmatic approach to acquiring preliminary evidence of efficacy through various complementary methods including a prospective cohort study, a geographical cluster investigation, virus phylogenetic analysis, virus surveillance in mosquitoes, and vector competence assays. This multipronged approach could provide valuable intermediate evidence of efficacy to justify a future cluster randomised trial.

AB - Dengue viruses cause more human morbidity and mortality than any other arthropod-borne virus. Dengue prevention relies mainly on vector control; however, the failure of traditional methods has promoted the development of novel entomological approaches. Although use of the intracellular bacterium wolbachia to control mosquito populations was proposed 50 years ago, only in the past decade has its use as a potential agent of dengue control gained substantial interest. Here, we review evidence that supports a practical approach for dengue reduction through field release of wolbachia-infected mosquitoes and discuss the additional studies that have to be done before the strategy can be validated and implemented. A crucial next step is to assess the efficacy of wolbachia in reducing dengue virus transmission. We argue that a cluster randomised trial is at this time premature because choice of wolbachia strain for release and deployment strategies are still being optimised. We therefore present a pragmatic approach to acquiring preliminary evidence of efficacy through various complementary methods including a prospective cohort study, a geographical cluster investigation, virus phylogenetic analysis, virus surveillance in mosquitoes, and vector competence assays. This multipronged approach could provide valuable intermediate evidence of efficacy to justify a future cluster randomised trial.

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