Abstract
The purpose of this study was to examine how using the mean of two consecutive measurements vs. one measurement post-treatment influences the sample size required to detect changes in cardiometabolic risk factors in dietary studies. For a given statistical power, using the mean of two measurements taken on consecutive days post-treatment instead of a single measurement significantly reduces the sample size required to observe changes in triglyceride, total apolipoprotein B100, and C-reactive protein concentrations in the context of a supplementation study. In the context of a controlled-feeding study, this gain is seen only in the case of change in triglyceride concentrations.
| Original language | English (US) |
|---|---|
| Journal | European Journal of Clinical Nutrition |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
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Assessing the impact of the diet on cardiometabolic outcomes : are multiple measurements post-intervention necessary? / Allaire, Janie; Talbot, Denis; Couture, Patrick; Tchernof, André; Jones, Peter J.H.; Kris-Etherton, Penny Margaret; West, Sheila Grace; Connelly, Philip W.; Jenkins, David J.A.; Lamarche, Benoît.
In: European Journal of Clinical Nutrition, 01.01.2018.Research output: Contribution to journal › Article
TY - JOUR
T1 - Assessing the impact of the diet on cardiometabolic outcomes
T2 - European Journal of Clinical Nutrition
AU - Allaire, Janie
AU - Talbot, Denis
AU - Couture, Patrick
AU - Tchernof, André
AU - Jones, Peter J.H.
AU - Kris-Etherton, Penny Margaret
AU - West, Sheila Grace
AU - Connelly, Philip W.
AU - Jenkins, David J.A.
AU - Lamarche, Benoît
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The purpose of this study was to examine how using the mean of two consecutive measurements vs. one measurement post-treatment influences the sample size required to detect changes in cardiometabolic risk factors in dietary studies. For a given statistical power, using the mean of two measurements taken on consecutive days post-treatment instead of a single measurement significantly reduces the sample size required to observe changes in triglyceride, total apolipoprotein B100, and C-reactive protein concentrations in the context of a supplementation study. In the context of a controlled-feeding study, this gain is seen only in the case of change in triglyceride concentrations.
AB - The purpose of this study was to examine how using the mean of two consecutive measurements vs. one measurement post-treatment influences the sample size required to detect changes in cardiometabolic risk factors in dietary studies. For a given statistical power, using the mean of two measurements taken on consecutive days post-treatment instead of a single measurement significantly reduces the sample size required to observe changes in triglyceride, total apolipoprotein B100, and C-reactive protein concentrations in the context of a supplementation study. In the context of a controlled-feeding study, this gain is seen only in the case of change in triglyceride concentrations.
UR - http://www.scopus.com/inward/record.url?scp=85051129744&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051129744&partnerID=8YFLogxK
U2 - 10.1038/s41430-018-0257-0
DO - 10.1038/s41430-018-0257-0
M3 - Article
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
ER -