Assessing the impact of the diet on cardiometabolic outcomes: are multiple measurements post-intervention necessary?

Janie Allaire, Denis Talbot, Patrick Couture, André Tchernof, Peter J.H. Jones, Penny Kris-Etherton, Sheila G. West, Philip W. Connelly, David J.A. Jenkins, Benoît Lamarche

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to examine how using the mean of two consecutive measurements vs. one measurement post-treatment influences the sample size required to detect changes in cardiometabolic risk factors in dietary studies. For a given statistical power, using the mean of two measurements taken on consecutive days post-treatment instead of a single measurement significantly reduces the sample size required to observe changes in triglyceride, total apolipoprotein B100, and C-reactive protein concentrations in the context of a supplementation study. In the context of a controlled-feeding study, this gain is seen only in the case of change in triglyceride concentrations.

Original languageEnglish (US)
Pages (from-to)1546-1550
Number of pages5
JournalEuropean Journal of Clinical Nutrition
Volume73
Issue number11
DOIs
StatePublished - Nov 1 2019

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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