Assessment of antiarrhythmic drug efficacy in the treatment of supraventricular arrhythmias

Gerald Naccarelli, Anne H. Dougherty, Ellison Berns, Robert L. Rinkenberger

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Few guidelines exist for judging the efficacy of antiarrhythmic drugs in patients with supraventricular arrhythmias. Useful definitions concerning the frequency and duration of supraventricular arrhythmias are offered, and complete and partial efficacy criteria are outlined for noninvasive electrocardiographic and invasive electrophysiologic techniques. Several open label, double-blind, parallel and crossover study designs are suggested for efficacy studies concerning the termination and prevention of supraventricular tachycardia. These recommendations are useful for designing new drug trials needed to evaluate properly the efficacy of antiarrhythmic agents in the treatment of various supraventricular arrhythmias.

Original languageEnglish (US)
JournalThe American Journal of Cardiology
Volume58
Issue number5
DOIs
StatePublished - Aug 29 1986

Fingerprint

Anti-Arrhythmia Agents
Cardiac Arrhythmias
Cross-Over Studies
Supraventricular Tachycardia
Double-Blind Method
Guidelines
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Naccarelli, Gerald ; Dougherty, Anne H. ; Berns, Ellison ; Rinkenberger, Robert L. / Assessment of antiarrhythmic drug efficacy in the treatment of supraventricular arrhythmias. In: The American Journal of Cardiology. 1986 ; Vol. 58, No. 5.
@article{f93216bb598d4cbdbc03fa6968efdfd9,
title = "Assessment of antiarrhythmic drug efficacy in the treatment of supraventricular arrhythmias",
abstract = "Few guidelines exist for judging the efficacy of antiarrhythmic drugs in patients with supraventricular arrhythmias. Useful definitions concerning the frequency and duration of supraventricular arrhythmias are offered, and complete and partial efficacy criteria are outlined for noninvasive electrocardiographic and invasive electrophysiologic techniques. Several open label, double-blind, parallel and crossover study designs are suggested for efficacy studies concerning the termination and prevention of supraventricular tachycardia. These recommendations are useful for designing new drug trials needed to evaluate properly the efficacy of antiarrhythmic agents in the treatment of various supraventricular arrhythmias.",
author = "Gerald Naccarelli and Dougherty, {Anne H.} and Ellison Berns and Rinkenberger, {Robert L.}",
year = "1986",
month = "8",
day = "29",
doi = "10.1016/0002-9149(86)90101-3",
language = "English (US)",
volume = "58",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "5",

}

Assessment of antiarrhythmic drug efficacy in the treatment of supraventricular arrhythmias. / Naccarelli, Gerald; Dougherty, Anne H.; Berns, Ellison; Rinkenberger, Robert L.

In: The American Journal of Cardiology, Vol. 58, No. 5, 29.08.1986.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Assessment of antiarrhythmic drug efficacy in the treatment of supraventricular arrhythmias

AU - Naccarelli, Gerald

AU - Dougherty, Anne H.

AU - Berns, Ellison

AU - Rinkenberger, Robert L.

PY - 1986/8/29

Y1 - 1986/8/29

N2 - Few guidelines exist for judging the efficacy of antiarrhythmic drugs in patients with supraventricular arrhythmias. Useful definitions concerning the frequency and duration of supraventricular arrhythmias are offered, and complete and partial efficacy criteria are outlined for noninvasive electrocardiographic and invasive electrophysiologic techniques. Several open label, double-blind, parallel and crossover study designs are suggested for efficacy studies concerning the termination and prevention of supraventricular tachycardia. These recommendations are useful for designing new drug trials needed to evaluate properly the efficacy of antiarrhythmic agents in the treatment of various supraventricular arrhythmias.

AB - Few guidelines exist for judging the efficacy of antiarrhythmic drugs in patients with supraventricular arrhythmias. Useful definitions concerning the frequency and duration of supraventricular arrhythmias are offered, and complete and partial efficacy criteria are outlined for noninvasive electrocardiographic and invasive electrophysiologic techniques. Several open label, double-blind, parallel and crossover study designs are suggested for efficacy studies concerning the termination and prevention of supraventricular tachycardia. These recommendations are useful for designing new drug trials needed to evaluate properly the efficacy of antiarrhythmic agents in the treatment of various supraventricular arrhythmias.

UR - http://www.scopus.com/inward/record.url?scp=0022507161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022507161&partnerID=8YFLogxK

U2 - 10.1016/0002-9149(86)90101-3

DO - 10.1016/0002-9149(86)90101-3

M3 - Article

VL - 58

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 5

ER -