Assessment of depression in multiple sclerosis: Development of a trunk and branch model

L. B. Strober, P. A. Arnett

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The objective of the present investigation was to improve the detection of depression in multiple sclerosis (MS). It has been hypothesized that the overlap of MS symptomatology and neurovegetative depression symptoms may lead to an over-diagnosis of depression in MS. Discerning what is depression and what is more attributable to the disease renders a complicated picture when assessing depression in medically ill people. Given this, trunk and branch models have been proposed. In such models trunk symptoms are purported to be the symptoms common to the medical condition and less likely reflective of depression. Branch items are those symptoms that are independent of the medical condition and likely reflect depression. In the present investigation we compared depressed individuals with MS, non-depressed individuals with MS, and non-depressed controls, to devise a trunk and branch model for use with individuals with MS. By identifying which symptoms are typical in MS, which exceed what is typical in MS, and which symptoms are independent of MS, but more often present in depressed individuals with MS, we hoped to present a better understanding of the nature of depression in MS.

Original languageEnglish (US)
Pages (from-to)1146-1166
Number of pages21
JournalClinical Neuropsychologist
Issue number7
StatePublished - Oct 2010

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Clinical Psychology
  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


Dive into the research topics of 'Assessment of depression in multiple sclerosis: Development of a trunk and branch model'. Together they form a unique fingerprint.

Cite this