Several studies and observations regarding past earthquakes such as 1989 Loma Prieta, 1994 Northridge, or 1999 Marmara earthquakes have shown the importance of lifeline systems functionality on response and recovery efforts. The general direction of studies on simulating lifelines seismic performance is towards achieving more accurate models to represent the system behavior. The methodology presented in this paper is a product of research conducted in the Mid-America Earthquake Center. Electric power, potable water, and natural gas networks are modeled as interacting systems where the state of one network is influenced by the state of another network. Interdependent network analysis methodology provides information on operational aspects of lifeline networks in post-seismic conditions in addition to structural damage assessment. These results are achieved by different components of the tool which are classified as structural and topological. The topological component analyzes the post seismic operability of the lifeline networks based on the damage assessment outcome of the structural model. Following an overview of the models, potential utilizations in different phases of disaster management are briefly discussed.