Assessment of potential therapies for acute T-2 toxicosis in the rat

Robert H. Poppenga, Val Richard Beasley, William B. Buck

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The efficacy of a variety of approaches for the treatment of animals with acute T-2 toxicosis was assessed utilizing young female rats. A single large dose of the water soluble salt of methylprednisolone significantly prolonged survival times in T-2 toxin treated animals. The use of diltiazem hydrochloride, dazemgrel, N-acetylcysteine, dimethyl sulfoxide, adenosine triphosphate (ATP), ATP combined with magnesium chloride, ascorbic acid, and aprotinin did not prolong survival times at the dosages administered. Trichodermin, a trichothecene similar in structure and biochemical activity to T-2 toxin but much less acutely toxic, had a detrimental effect on survival times whether given 1 hr prior to or after T-2 toxin.

Original languageEnglish (US)
Pages (from-to)537-546
Number of pages10
JournalToxicon
Volume25
Issue number5
DOIs
StatePublished - 1987

All Science Journal Classification (ASJC) codes

  • Toxicology

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