TY - JOUR
T1 - Assessment of the Minimum Number of Lymph Nodes Needed to Detect Lymph Node Invasion at Radical Nephroureterectomy in Patients With Upper Tract Urothelial Cancer
AU - Roscigno, Marco
AU - Shariat, Shahrokh F.
AU - Freschi, Massimo
AU - Margulis, Vitaly
AU - Karakiewizc, Pierre
AU - Suardi, Nazareno
AU - Remzi, Mesut
AU - Zigeuner, Richard
AU - Bolenz, Christian
AU - Kikuchi, Eiji
AU - Weizer, Alon
AU - Bensalah, Karim
AU - Sagalowsky, Arthur
AU - Koppie, Theresa M.
AU - Raman, Jay
AU - Fernández, Mario
AU - Ströbel, Philipp
AU - Kabbani, Wareef
AU - Langner, Cord
AU - Wheat, Jeffery
AU - Guo, Charles C.
AU - Kassouf, Wassim
AU - Haitel, Andrea
AU - Wood, Christopher G.
AU - Montorsi, Francesco
PY - 2009/11/1
Y1 - 2009/11/1
N2 - Objectives: To determine whether a minimum number of lymph nodes (LNs) exist to detect lymph node invasion (LNI) in patients undergoing radical nephroureterectomy (RNU) for upper tract urothelial carcinoma. Methods: The study included 551 consecutive patients, from 13 centers worldwide, who underwent RNU and lymphadenectomy (LND) between 1992 and 2006. LND was performed at the discretion of the surgeon. All pathological slides were re-reviewed by uropathologists according to strict criteria. Receiver-operating characteristic curve coordinates were used to determine the probability of diagnosing LNI according to the total number of nodes removed. Additionally, the relationship between the number of nodes removed and the rate of positive LNs was tested in univariate and multivariate logistic regression models. Results: Median patient age was 68 years (range: 27-97). Of 551 patients, 140 (25.4%) had positive lymph nodes. Median number of lymph nodes removed was 5 (mean 6.7, range 1-41). The Receiver-operating characteristic coordinates plot indicated that the removal of 13 nodes yielded a 90% probability to detect ≥1 positive LNs. The removal of 8 nodes resulted in a 75% probability of finding ≥1 positive nodes. Removal of >8 LNs (P = .03; odds ratio 1.49) was independently associated with LNI after adjusting for pathological stage and grade. Conclusions: Our data indicate that 8 LNs need to be removed at radical nephroureterectomy to achieve a 75% probability of finding ≥1 positive nodes. Further improvement of the specificity of LND will require the removal of more lymph nodes.
AB - Objectives: To determine whether a minimum number of lymph nodes (LNs) exist to detect lymph node invasion (LNI) in patients undergoing radical nephroureterectomy (RNU) for upper tract urothelial carcinoma. Methods: The study included 551 consecutive patients, from 13 centers worldwide, who underwent RNU and lymphadenectomy (LND) between 1992 and 2006. LND was performed at the discretion of the surgeon. All pathological slides were re-reviewed by uropathologists according to strict criteria. Receiver-operating characteristic curve coordinates were used to determine the probability of diagnosing LNI according to the total number of nodes removed. Additionally, the relationship between the number of nodes removed and the rate of positive LNs was tested in univariate and multivariate logistic regression models. Results: Median patient age was 68 years (range: 27-97). Of 551 patients, 140 (25.4%) had positive lymph nodes. Median number of lymph nodes removed was 5 (mean 6.7, range 1-41). The Receiver-operating characteristic coordinates plot indicated that the removal of 13 nodes yielded a 90% probability to detect ≥1 positive LNs. The removal of 8 nodes resulted in a 75% probability of finding ≥1 positive nodes. Removal of >8 LNs (P = .03; odds ratio 1.49) was independently associated with LNI after adjusting for pathological stage and grade. Conclusions: Our data indicate that 8 LNs need to be removed at radical nephroureterectomy to achieve a 75% probability of finding ≥1 positive nodes. Further improvement of the specificity of LND will require the removal of more lymph nodes.
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U2 - 10.1016/j.urology.2009.04.084
DO - 10.1016/j.urology.2009.04.084
M3 - Article
C2 - 19883824
AN - SCOPUS:70350489253
SN - 0090-4295
VL - 74
SP - 1070
EP - 1074
JO - Urology
JF - Urology
IS - 5
ER -