Assessments of fatty infiltration and muscle atrophy from a single magnetic resonance image slice are not predictive of 3-dimensional measurements

Meghan E. Vidt, Anthony C. Santago, Christopher J. Tuohy, Gary G. Poehling, Michael T. Freehill, Robert A. Kraft, Anthony P. Marsh, Eric J. Hegedus, Michael E. Miller, Katherine R. Saul

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Purpose To (1) determine whether standard clinical muscle fatty infiltration and atrophy assessment techniques using a single image slice for patients with a rotator cuff tear (RCT) are correlated with 3-dimensional measures in older individuals (60+ years) and (2) to determine whether age-associated changes to muscle morphology and strength are compounded by an RCT. Methods Twenty older individuals were studied: 10 with an RCT of the supraspinatus (5 men and 5 women) and 10 matched controls. Clinical imaging assessments (Goutallier and Fuchs scores and cross-sectional area ratio) were performed for participants with RCTs. Three-dimensional measurements of rotator cuff muscle and fat tissues were obtained for all participants using magnetic resonance imaging (MRI). Isometric joint moment was measured at the shoulder. Results There were no significant associations between single-image assessments and 3-dimensional measurements of fatty infiltration for the supraspinatus and infraspinatus muscles. Compared with controls, participants with RCTs had significantly increased percentages of fatty infiltration for each rotator cuff muscle (all P ≤.023); reduced whole muscle volume for the supraspinatus, infraspinatus, and subscapularis muscles (all P ≤.038); and reduced fat-free muscle volume for the supraspinatus, infraspinatus, and subscapularis muscles (all P ≤.027). Only the teres minor (P =.017) fatty infiltration volume was significantly greater for participants with RCTs. Adduction, flexion, and external rotation strength (all P ≤.021) were significantly reduced for participants with RCTs, and muscle volume was a significant predictor of strength for all comparisons. Conclusions Clinical scores using a single image slice do not represent 3-dimensional muscle measurements. Efficient methods are needed to more effectively capture 3-dimensional information for clinical applications. Participants with RCTs had increased fatty infiltration percentages that were likely driven by muscle atrophy rather than increased fat volume. The significant association of muscle volume with strength production suggests that treatments to preserve muscle volume should be pursued for older patients with RCTs. Level of Evidence Level II, diagnostic study, with development of diagnostic criteria on the basis of consecutive patients with universally applied reference gold standard.

Original languageEnglish (US)
Pages (from-to)128-139
Number of pages12
JournalArthroscopy - Journal of Arthroscopic and Related Surgery
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2016

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Rotator Cuff
Muscular Atrophy
Magnetic Resonance Spectroscopy
Muscles
Fats
Muscle Strength
Atrophy
Joints
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

Cite this

Vidt, Meghan E. ; Santago, Anthony C. ; Tuohy, Christopher J. ; Poehling, Gary G. ; Freehill, Michael T. ; Kraft, Robert A. ; Marsh, Anthony P. ; Hegedus, Eric J. ; Miller, Michael E. ; Saul, Katherine R. / Assessments of fatty infiltration and muscle atrophy from a single magnetic resonance image slice are not predictive of 3-dimensional measurements. In: Arthroscopy - Journal of Arthroscopic and Related Surgery. 2016 ; Vol. 32, No. 1. pp. 128-139.
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abstract = "Purpose To (1) determine whether standard clinical muscle fatty infiltration and atrophy assessment techniques using a single image slice for patients with a rotator cuff tear (RCT) are correlated with 3-dimensional measures in older individuals (60+ years) and (2) to determine whether age-associated changes to muscle morphology and strength are compounded by an RCT. Methods Twenty older individuals were studied: 10 with an RCT of the supraspinatus (5 men and 5 women) and 10 matched controls. Clinical imaging assessments (Goutallier and Fuchs scores and cross-sectional area ratio) were performed for participants with RCTs. Three-dimensional measurements of rotator cuff muscle and fat tissues were obtained for all participants using magnetic resonance imaging (MRI). Isometric joint moment was measured at the shoulder. Results There were no significant associations between single-image assessments and 3-dimensional measurements of fatty infiltration for the supraspinatus and infraspinatus muscles. Compared with controls, participants with RCTs had significantly increased percentages of fatty infiltration for each rotator cuff muscle (all P ≤.023); reduced whole muscle volume for the supraspinatus, infraspinatus, and subscapularis muscles (all P ≤.038); and reduced fat-free muscle volume for the supraspinatus, infraspinatus, and subscapularis muscles (all P ≤.027). Only the teres minor (P =.017) fatty infiltration volume was significantly greater for participants with RCTs. Adduction, flexion, and external rotation strength (all P ≤.021) were significantly reduced for participants with RCTs, and muscle volume was a significant predictor of strength for all comparisons. Conclusions Clinical scores using a single image slice do not represent 3-dimensional muscle measurements. Efficient methods are needed to more effectively capture 3-dimensional information for clinical applications. Participants with RCTs had increased fatty infiltration percentages that were likely driven by muscle atrophy rather than increased fat volume. The significant association of muscle volume with strength production suggests that treatments to preserve muscle volume should be pursued for older patients with RCTs. Level of Evidence Level II, diagnostic study, with development of diagnostic criteria on the basis of consecutive patients with universally applied reference gold standard.",
author = "Vidt, {Meghan E.} and Santago, {Anthony C.} and Tuohy, {Christopher J.} and Poehling, {Gary G.} and Freehill, {Michael T.} and Kraft, {Robert A.} and Marsh, {Anthony P.} and Hegedus, {Eric J.} and Miller, {Michael E.} and Saul, {Katherine R.}",
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Assessments of fatty infiltration and muscle atrophy from a single magnetic resonance image slice are not predictive of 3-dimensional measurements. / Vidt, Meghan E.; Santago, Anthony C.; Tuohy, Christopher J.; Poehling, Gary G.; Freehill, Michael T.; Kraft, Robert A.; Marsh, Anthony P.; Hegedus, Eric J.; Miller, Michael E.; Saul, Katherine R.

In: Arthroscopy - Journal of Arthroscopic and Related Surgery, Vol. 32, No. 1, 01.01.2016, p. 128-139.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Assessments of fatty infiltration and muscle atrophy from a single magnetic resonance image slice are not predictive of 3-dimensional measurements

AU - Vidt, Meghan E.

AU - Santago, Anthony C.

AU - Tuohy, Christopher J.

AU - Poehling, Gary G.

AU - Freehill, Michael T.

AU - Kraft, Robert A.

AU - Marsh, Anthony P.

AU - Hegedus, Eric J.

AU - Miller, Michael E.

AU - Saul, Katherine R.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Purpose To (1) determine whether standard clinical muscle fatty infiltration and atrophy assessment techniques using a single image slice for patients with a rotator cuff tear (RCT) are correlated with 3-dimensional measures in older individuals (60+ years) and (2) to determine whether age-associated changes to muscle morphology and strength are compounded by an RCT. Methods Twenty older individuals were studied: 10 with an RCT of the supraspinatus (5 men and 5 women) and 10 matched controls. Clinical imaging assessments (Goutallier and Fuchs scores and cross-sectional area ratio) were performed for participants with RCTs. Three-dimensional measurements of rotator cuff muscle and fat tissues were obtained for all participants using magnetic resonance imaging (MRI). Isometric joint moment was measured at the shoulder. Results There were no significant associations between single-image assessments and 3-dimensional measurements of fatty infiltration for the supraspinatus and infraspinatus muscles. Compared with controls, participants with RCTs had significantly increased percentages of fatty infiltration for each rotator cuff muscle (all P ≤.023); reduced whole muscle volume for the supraspinatus, infraspinatus, and subscapularis muscles (all P ≤.038); and reduced fat-free muscle volume for the supraspinatus, infraspinatus, and subscapularis muscles (all P ≤.027). Only the teres minor (P =.017) fatty infiltration volume was significantly greater for participants with RCTs. Adduction, flexion, and external rotation strength (all P ≤.021) were significantly reduced for participants with RCTs, and muscle volume was a significant predictor of strength for all comparisons. Conclusions Clinical scores using a single image slice do not represent 3-dimensional muscle measurements. Efficient methods are needed to more effectively capture 3-dimensional information for clinical applications. Participants with RCTs had increased fatty infiltration percentages that were likely driven by muscle atrophy rather than increased fat volume. The significant association of muscle volume with strength production suggests that treatments to preserve muscle volume should be pursued for older patients with RCTs. Level of Evidence Level II, diagnostic study, with development of diagnostic criteria on the basis of consecutive patients with universally applied reference gold standard.

AB - Purpose To (1) determine whether standard clinical muscle fatty infiltration and atrophy assessment techniques using a single image slice for patients with a rotator cuff tear (RCT) are correlated with 3-dimensional measures in older individuals (60+ years) and (2) to determine whether age-associated changes to muscle morphology and strength are compounded by an RCT. Methods Twenty older individuals were studied: 10 with an RCT of the supraspinatus (5 men and 5 women) and 10 matched controls. Clinical imaging assessments (Goutallier and Fuchs scores and cross-sectional area ratio) were performed for participants with RCTs. Three-dimensional measurements of rotator cuff muscle and fat tissues were obtained for all participants using magnetic resonance imaging (MRI). Isometric joint moment was measured at the shoulder. Results There were no significant associations between single-image assessments and 3-dimensional measurements of fatty infiltration for the supraspinatus and infraspinatus muscles. Compared with controls, participants with RCTs had significantly increased percentages of fatty infiltration for each rotator cuff muscle (all P ≤.023); reduced whole muscle volume for the supraspinatus, infraspinatus, and subscapularis muscles (all P ≤.038); and reduced fat-free muscle volume for the supraspinatus, infraspinatus, and subscapularis muscles (all P ≤.027). Only the teres minor (P =.017) fatty infiltration volume was significantly greater for participants with RCTs. Adduction, flexion, and external rotation strength (all P ≤.021) were significantly reduced for participants with RCTs, and muscle volume was a significant predictor of strength for all comparisons. Conclusions Clinical scores using a single image slice do not represent 3-dimensional muscle measurements. Efficient methods are needed to more effectively capture 3-dimensional information for clinical applications. Participants with RCTs had increased fatty infiltration percentages that were likely driven by muscle atrophy rather than increased fat volume. The significant association of muscle volume with strength production suggests that treatments to preserve muscle volume should be pursued for older patients with RCTs. Level of Evidence Level II, diagnostic study, with development of diagnostic criteria on the basis of consecutive patients with universally applied reference gold standard.

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