Abstract

Observability of a dynamical system requires an understanding of its state-the collective values of its variables. However, existing techniques are too limited to measure all but a small fraction of the physical variables and parameters of neuronal networks. We constructed models of the biophysical properties of neuronal membrane, synaptic, and microenvironment dynamics, and incorporated them into a model-based predictor-controller framework from modern control theory. We demonstrate that it is now possible to meaningfully estimate the dynamics of small neuronal networks using as few as a single measured variable. Specifically, we assimilate noisy membrane potential measurements from individual hippocampal neurons to reconstruct the dynamics of networks of these cells, their extracellular microenvironment, and the activities of different neuronal types during seizures. We use reconstruction to account for unmeasured parts of the neuronal system, relating micro-domain metabolic processes to cellular excitability, and validate the reconstruction of cellular dynamical interactions against actual measurements. Data assimilation, the fusing of measurement with computational models, has significant potential to improve the way we observe and understand brain dynamics.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalPLoS Computational Biology
Volume6
Issue number5
DOIs
StatePublished - May 1 2010

Fingerprint

Synaptic Membranes
seizures
Membrane Potentials
Seizures
Neurons
Neuronal Network
Brain
membrane
Membranes
data assimilation
Excitability
Membrane Potential
Data Assimilation
brain
Observability
controllers
Control theory
Control Theory
membrane potential
Computational Model

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Modeling and Simulation
  • Ecology
  • Molecular Biology
  • Genetics
  • Cellular and Molecular Neuroscience
  • Computational Theory and Mathematics

Cite this

Ullah, Ghanim ; Schiff, Steven. / Assimilating seizure dynamics. In: PLoS Computational Biology. 2010 ; Vol. 6, No. 5. pp. 1-12.
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Assimilating seizure dynamics. / Ullah, Ghanim; Schiff, Steven.

In: PLoS Computational Biology, Vol. 6, No. 5, 01.05.2010, p. 1-12.

Research output: Contribution to journalArticle

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